Effect of Giving Michelia Champaca Linn Extract on Histopathology of Uterus and Ovary in Menopausal Rats

DOI

10.2991/978-94-6463-184-5_25How to use a DOI?

Keywords

Michelia Champaca Linn; Histopathology; Uterus; Ovaries; Menopause

Abstract

Purpose: This study was conducted to determine the effect of giving Michelia Champaca Linn Extract on the histopathology of the uterus and ovaries in menopausal rats.

Methodology: This was an experimental design with a posttest only control group design approach. This study used 28 menopausal Rattus Novergicus Strain Wistar rats, which were divided into 4 groups selected randomly. The control group was given a placebo, three treatment groups were given the extract of Michellia Champaca L dose one, dose two and dose three.

Results: Our analysis showed on histopathological observation of mucosal inflammatory cells in the uterus, it was shown that the p-value of 0.000. So does in observation of uterine bleeding and uterine necrosis. These results showed that there were a significant effect of giving Michelia Champaca Linn Extract. On the other hand, in observation of uterine congestion, it was shown that p-value of 0.125 proves that there was no significant effect of giving Michelia Champaca L extract on uterine congestion. Meanwhile, on histopathological observation of hemorrhage in the ovaries, it was shown p-value of 0.236 and observation of vacuolization of the ovarium, it shown p-value 0.306. So there were no significant effect of giving Michelia Champaca Linn Extract. Different result found at observation of ovarian congestion and oocytes in the ovaries, each of them showed p-value of 0.022 and 0.021, proves that there were a significant effect of giving Michelia Champaca Linn Extract.

Applications/Originality/Value: Michelia Champaca Linn extract has the potential as a natural estrogen replacement which begins to disappear during menopause.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Endang Sri Wahyuni
AU  - Maryatun Maryatun
AU  - Siska Ningtyas Prabasari
AU  - Riyani Wulandari
AU  - Lely Firrahmawati
AU  - Endah Sri Wahyuni
AU  - Asti Nur Hayati
PY  - 2023
DA  - 2023/05/30
TI  - Effect of Giving Michelia Champaca Linn Extract on Histopathology of Uterus and Ovary in Menopausal Rats
BT  - Proceedings of the International Conference on Health and Well-Being (ICHWB 2022)
PB  - Atlantis Press
SP  - 263
EP  - 273
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-184-5_25
DO  - 10.2991/978-94-6463-184-5_25
ID  - Wahyuni2023
ER  -