The Potential of Guafit Powder Capsules as an ACE-2 Inhibitor
(An in Silico Study)
- DOI
- 10.2991/assehr.k.220305.063How to use a DOI?
- Keywords
- red guava; antioxidant; ACE-2 inhibitor; medicinal plants; supplements products
- Abstract
Batu City in Indonesia is an agricultural area with excellent commodities, one of which is red guava fruit, known to have a higher vitamin C than oranges as an antioxidant. Meanwhile, the farmers often encounter abundant crop obstacles; it is usually processed into fruit chips. However, the manufacturing heating process can degrade its nutrients. Packaging of guava powder in capsules can become an answer to process natural products, preserve their nutrition and add more value to the commodity. In addition, during the Covid-19 pandemic, the health supplements product rich in vitamin C and antioxidants are necessitated to help stimulate healing and enhance immunity. Objective: To identify drug candidates from bioactive compounds in guava fruit through virtual screening and test potential inhibitors of ACE-2 activity. Methods: Samples were prepared from several bioactive compounds of guava fruit: ascorbic acid, gallic acid, quercetin, and chlorogenic acid. They were then analyzed using the drug-likeness test, molecular docking, and chemical bond interaction and molecular visualization analysis. Result: Quercetin and chlorogenic acids in guava can trigger ACE-2 inhibition by binding to the active site with weak bond interactions. Conclusion: The bioactive of guava fruit is proven in silico to inhibit the activity of ACE-2.
- Copyright
- © 2022 The Authors. Published by Atlantis Press SARL.
- Open Access
- This is an open access article under the CC BY-NC license.
Cite this article
TY - CONF AU - Ratih Pusporini AU - Nenny Prasetyaningrum AU - Oktavia Eka Puspita PY - 2022 DA - 2022/03/30 TI - The Potential of Guafit Powder Capsules as an ACE-2 Inhibitor BT - Proceedings of the 4th International Conference on Innovation in Engineering and Vocational Education (ICIEVE 2021) PB - Atlantis Press SP - 313 EP - 316 SN - 2352-5398 UR - https://doi.org/10.2991/assehr.k.220305.063 DO - 10.2991/assehr.k.220305.063 ID - Pusporini2022 ER -