The Effect of Quercetin for Salt Induces Renal Fibrosis by Suppressing Collagen Production

DOI

10.2991/icihc-18.2019.77How to use a DOI?

Keywords

quercetin, TGF-β1, collagen volume fraction, NaCl, renal fibrosis.

Abstract

The bad effect of salt have been suspected for a least one hundred years. High salt intake increased production of TGF-β where as TGF-β activates a receptor serine/threonine kinase (RS/TK). Through phosphorylation Smad2/3 and Co-Smad cascade they recruited transcription factors and co-activator for initiates gene transcription for cell proliferation, cell diferentiation and extramatriks celuller production include collagen. This mecanisms initiate renal fibrosis. This study was a quasi experimental research with post-test only group design. Subject were 24 male wistar rat induced with 2%/kgBB dose of NaCl 8%. The subjects were divided in to six groups. NaCl 8% and quercetin was delivered by gavage daily for 8 weeks. After threatment the kidneys were taken for quantification the collagen volume fraction were stained with picrosirius red then quantification by Image J software. The level of Glomerular volume collagen fraction group OO (3.78+0.12 %), NO (19.05+0.99 %), NK5 (19.42+3.19 %) NK10 (17.14+0.70 %) and NK20 (3.22+0.81). Tubular volume collagen fraction group OO (2.26+0.08 %), NO (9.79+0.53 %), NK5 (9.72+0.98 %), NK10 (5.25+0.49 %), NK20 (1.92+0.20 %). Our data indicate that quercetin may supressing the collage volume fraction with significant difference in the dose of 20 mg/kg BB quercetin.

Copyright

© 2019, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Widia Lestari
AU  - Sri Lestari Sulistyo Rini
PY  - 2019/04
DA  - 2019/04
TI  - The Effect of Quercetin for Salt Induces Renal Fibrosis by Suppressing Collagen Production
BT  - Proceedings of the 1st International Conference on Inter-professional Health Collaboration (ICIHC 2018)
PB  - Atlantis Press
SP  - 360
EP  - 363
SN  - 2468-5739
UR  - https://doi.org/10.2991/icihc-18.2019.77
DO  - 10.2991/icihc-18.2019.77
ID  - Lestari2019/04
ER  -