Analyze the Drug Regularity in the Prescription to the Treatment of Primary Hepatocellular Carcinoma by R Language

DOI

10.2991/icmcs-18.2018.78How to use a DOI?

Keywords

R language; Liver cancer; Drug pairs; Cluster; Associate

Abstract

Object Application of R language to analyze the drug regularity in the treatment of primary hepatocellular carcinoma by traditional Chinese Medicine. Method Retrieval of the traditional Chinese medicine knowledge database in Chinese Wan-fang Database and extract the prescription for the treatment of primary hepatocellular carcinoma. Drug and symptom data set was built by Excel, and applied R language for frequency analyses, cluster analyses and association analyses, then draw the cluster diagram and associated graph. Results The common drugs used in the treatment of liver cancer are Hedyotis diffusa, Glycyrrhiza, Atractylodes, Scutellariae barbata, Lanceolata, Salvia, Curcuma Longa, Bupleurum, Poria and Peony root in turn. The common drug pairs were Astragalus-Glycyrrhiza, Poria-Atractylodes, Lanceolata-Atractylodes, Lanceolata-Glycyrrhiza, Scutellariae barbata-Salvia. Hedyotis diffusa often composition of the drug pair with Glycyrrhiza, Glycyrrhiza and Lanceolata. Single drug of Gardenia, Bupleurum, Astragalus, Scutellariae barbata and Pinellia were often used for the pain of liver, while the drug pairs were Pinellia-Bupleurum, Hedyotis diffusa-Astragalus, Bupleurum-Poria, Scutellariae barbata- Bupleurum and Bupleurum-Curcuma Longa. Conclusion Application of the R language for data mining of traditional Chinese medicine database can effectively explore the rule of drug treatment for liver cancer, and has a certain value for further elucidating the pharmacological mechanism of traditional Chinese medicine prescriptions and guiding the clinical use of drugs.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Yexing Wang
AU  - Jingyi Liu
AU  - Zhilei Jiang
AU  - Jian Gong
PY  - 2018/10
DA  - 2018/10
TI  - Analyze the Drug Regularity in the Prescription to the Treatment of Primary Hepatocellular Carcinoma by R Language
BT  - Proceedings of the 8th International Conference on Management and Computer Science (ICMCS 2018)
PB  - Atlantis Press
SP  - 382
EP  - 388
SN  - 2352-538X
UR  - https://doi.org/10.2991/icmcs-18.2018.78
DO  - 10.2991/icmcs-18.2018.78
ID  - Wang2018/10
ER  -