Correlation of Alzheimer's Disease with Wnt Signaling Pathway and Neural Stem Cells
- Hongbo Yao, Lihui Sun, Jie Lian, Meng Zhang, Danyang Liu
- Corresponding Author
- Hongbo Yao
Available Online December 2015.
- https://doi.org/10.2991/icmmcce-15.2015.22How to use a DOI?
- Alzheimer's Disease, Wnt Signaling Pathway, Neural Stem Cells.
- Recent studies have shown that Wnt signaling molecules and the occurrence and development of Alzheimer's disease are closely related. Wnt protein secretion by autocrine or located next to the cell membrane receptor binding, activation of intracellular signaling pathways to regulate expression of target genes of cell proliferation during embryonic development, differentiation, migration, polarity and apoptosis has played an important role. The pathological mechanism of Alzheimer's disease involves inherited, environmental and immunological factors. Strong evidence exists that Wnt signaling pathway is closely related to the pathological process of Alzheimer's disease. There is also evidence that Wnt signaling pathway plays a crucial effect on the proliferation of neural stem cells. To review the relationship between pathological process of Alzheimer's disease and Wnt signaling pathway and effects of Wnt signaling on proliferation and differentiation of neural stem cells, providing theoretical evidence for treatment of Alzheimer's disease.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Hongbo Yao AU - Lihui Sun AU - Jie Lian AU - Meng Zhang AU - Danyang Liu PY - 2015/12 DA - 2015/12 TI - Correlation of Alzheimer's Disease with Wnt Signaling Pathway and Neural Stem Cells BT - 2015 4th International Conference on Mechatronics, Materials, Chemistry and Computer Engineering PB - Atlantis Press SN - 2352-538X UR - https://doi.org/10.2991/icmmcce-15.2015.22 DO - https://doi.org/10.2991/icmmcce-15.2015.22 ID - Yao2015/12 ER -