Synthesis of 5-Substituted Indole-2,3-dione
Dandan Zhao, Ping Wang, Tongsheng Xu, JieLian Wu, Jiajia Wang, Shan Xu
Available Online March 2016.
- https://doi.org/10.2991/icmmct-16.2016.152How to use a DOI?
- 4-Substituted isonitroacetanilines, 5-Substituted indol-2,3-dione,Synthesis
- 4-Substituted isonitroacetanilines 2 were prepared by the reaction of 4-substituted anilines 3 with chloral hydrate and hydroxylamine hydrochloride. 5-Substituted indol-2,3-dione 1 were prepared by the cyclization of 2 in the presence of concentrated sulfuric acid. 5-Substituted indol-2,3-dione 1 is an important intermediate in many biologically active compounds. The structure was confirmed by mass spectra (MS). Furthermore, the synthetic method was optimized. The total yield of the two steps was 51-68%(calculated from 4-substituted anilines).
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Cite this article
TY - CONF AU - Dandan Zhao AU - Ping Wang AU - Tongsheng Xu AU - JieLian Wu AU - Jiajia Wang AU - Shan Xu PY - 2016/03 DA - 2016/03 TI - Synthesis of 5-Substituted Indole-2,3-dione BT - Proceedings of the 2016 4th International Conference on Machinery, Materials and Computing Technology PB - Atlantis Press SP - 776 EP - 779 SN - 2352-5401 UR - https://doi.org/10.2991/icmmct-16.2016.152 DO - https://doi.org/10.2991/icmmct-16.2016.152 ID - Zhao2016/03 ER -