Profile Histopathology Analysis of Gastric, Duodenum, Ileum, and Colon of Inflammatory Bowel Disease (IBD) Rat Model
Dhita Evi Aryani, Aulanni'am Aulanni'am, Agri Kaltaria Anisa, Wawid Purwatiningsih
Dhita Evi Aryani
Available Online July 2017.
- https://doi.org/10.2991/icoh-17.2018.23How to use a DOI?
- inflammatory bowel disease, histopathology, indomethacin
- Inflammatory bowel disease (IBD) is a disease that is mediated by the immune system that affects the gastrointestinal tract, especially the colon mucosa. This disease will cause diarrhea and mucosal damage. In general, IBD is caused by viruses and bacteria that infect the gastrointestinal tract, but some studies suggests that IBD can also be caused by side effects of non-steroidal anti-inflammatory drugs such as indomethacin.The aim of this research was to determine and compare the profile of organ histopathology, such as gastric, ileum, duodenum, and colon of normal and IBD rats. This research was a preliminary research in the course of obtaining alternative therapies for IBD derived from natural materials. Methods of this research was rats were divided into two groups, namely normal rats group and IBD rats group induced orally with indomethacin at a dose of 15 mg/KgBB once. A condition resembling IBD was present and was observed after 24 hours and the rats were euthanized. Histopathology analysis of gastric, ileum, duodenum, and colon of normal and IBD rats was done qualitatively using Hematoxylin Eosin (HE) colouring and was reported descriptively. Results of the histopathology analysis showed that some damages, such as mucosal damage, ulceration, erosion, congestion, vasodilatation, and inflammatory cell infiltration was observed in the histopathology of the gastric, duodenum, ileum and colon of IBD rats compared to the same organ histopathology of normal rats.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Dhita Evi Aryani AU - Aulanni'am Aulanni'am AU - Agri Kaltaria Anisa AU - Wawid Purwatiningsih PY - 2017/07 DA - 2017/07 TI - Profile Histopathology Analysis of Gastric, Duodenum, Ileum, and Colon of Inflammatory Bowel Disease (IBD) Rat Model BT - 1st International Conference in One Health (ICOH 2017) PB - Atlantis Press SP - 113 EP - 117 SN - 2468-5739 UR - https://doi.org/10.2991/icoh-17.2018.23 DO - https://doi.org/10.2991/icoh-17.2018.23 ID - Aryani2017/07 ER -