Potency Combination of Curcumin (Curcuma longa Linn.) and Vitamin E Toward Estrogen and Progesterone Profile on Rat (Ratttus norvegicus) Mammary Cancer Model

DOI

10.2991/icoh-17.2018.67How to use a DOI?

Keywords

Curcumin, Vitamin E, Mammary cancer.

Abstract

This study aimed to determine the potency of combination of medicinal plants, which is curcumin and vitamin E as an alternative herbal for breast cancer treatment using DMBA ((7,12-Dimethylbenz(a)anthracene) induced rats (Rattus norvegicus) as animal model. The treatments were normal rats as negative control group (NCG), DMBA induced rats as breast cancer suffering rats or positive control group (PCG), and DMBA induced rats treated with combination of curcumin 72 mg per kg body weight per day and vitamin E 200 IU per head per day for 14 days as treated positive control group 1 (TPCG 1) and DMBA induced rats as breast cancer suffering rats or positive control group (PCG), and DMBA induced rats treated with combination of curcumin 48 mg per kg body weight per day and vitamin E 300 IU per head per day for 14 days as treated positive control group 2 (TPCG 2). Therapy of the DMBA induced rats was done per orally using combination of curcumin 72 mg per kg body weight per day and vitamin E 200 IU per head per day for 14 days. After the 14 days, euthanasia was done on the rats and blood samples were collected from each rat for laboratory analysis of estrogen and progesterone concentration using Enzyme Linked Immunosorbent Assay (ELISA) procedure. It was clearly shown that combination of curcumin 72 mg per kg body weight per day and vitamin E 200 IU per head per day has potential as an anti cancer therapy, as characterized by the decrease of blood estrogen concentration, the increase of blood progesterone concentration, and the disappearance of nodules in the breast tissues of cancer suffering animals.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

TY  - CONF
AU  - Herawati Herawati
AU  - Aulia Firmawati
AU  - Dyah Ayu Oktavianie Ardhiana Pratama
AU  - Anna Roosdiana
PY  - 2017/07
DA  - 2017/07
TI  - Potency Combination of Curcumin (Curcuma longa Linn.) and Vitamin E Toward Estrogen and Progesterone Profile on Rat (Ratttus norvegicus) Mammary Cancer Model
BT  - Proceedings of the 1st International Conference in One Health (ICOH 2017)
PB  - Atlantis Press
SP  - 329
EP  - 332
SN  - 2468-5739
UR  - https://doi.org/10.2991/icoh-17.2018.67
DO  - 10.2991/icoh-17.2018.67
ID  - Herawati2017/07
ER  -