Proceedings of the 4th International Conference on Life Sciences and Biotechnology (ICOLIB 2021)

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The Roles of Genetic and Epigenetic Aspects in Mandibular Prognathism: A Review

Authors
Putri Fatimatus Zahro1, Francisca Veyta Ayu2, Fadli Jazaldi3, Elza Ibrahim Auerkari4, *
1Orthodontic Residency Program, Faculty of Dentistry, University of Indonesia, Salemba Raya Street, No. 4, Jakarta, 10430, Indonesia
2Master Program of Basic Dental Science - Forensic Odontology, Faculty of Dentistry, University of Indonesia, Kampus UI Salemba, Jakarta, 10430, Indonesia
3Department of Orthodontics, Faculty of Dentistry, University of Indonesia, Salemba Raya Street, No. 4, Jakarta, 10430, Indonesia
4Department of Oral Biology-Division Forensic Odontology, Faculty of Dentistry, University of Indonesia, Salemba Raya Street, No. 4, Jakarta, 10430, Indonesia
*Corresponding author. Email: elza.ibrahim@ui.ac.id
Corresponding Author
Elza Ibrahim Auerkari
Available Online 22 December 2022.
DOI
10.2991/978-94-6463-062-6_27How to use a DOI?
Keywords
Mandibular Prognathism; Genetic; Environment; Epigenetic; Etiology
Abstract

Individuals with mandibular prognathism (MP) are characterized by a concave facial profile, and in severe cases, an extremely long face. These clinical characteristics mostly result from the extreme forward growth of the mandible, and are more prevalent in Asians than in Caucasians. MP is a multifactorial condition, with genetic, environment or their interaction (including epigenetics) as assumed etiological factors. As suggested by familial and ethnic traits, the genetic aspects are important, and MP has been found to have a relationship with numerous loci and genes. The present review aims to assess studies on the potential association of MP with the candidate genes of MYO1H, RUNX2 and MATN1, and interactions between genes and environment. The results showed mechanisms of expression correlated genes developing MP. The interactions between these genes and others, or between the genes and the environment (epigenetics), have not been clearly demonstrated, except for the RUNX2 gene that correlates with observed K(lysine) acetyltransferase 6B (KAT6B) and histone deacetylase 4 (HDAC4). In conclusion, the expression of MYO1H, RUNX2, and MATN1 genes is indicated to play a vital role in genetic and epigenetic regulation to develop the phenotype of MP.

Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 4th International Conference on Life Sciences and Biotechnology (ICOLIB 2021)
Series
Advances in Biological Sciences Research
Publication Date
22 December 2022
ISBN
10.2991/978-94-6463-062-6_27
ISSN
2468-5747
DOI
10.2991/978-94-6463-062-6_27How to use a DOI?
Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Putri Fatimatus Zahro
AU  - Francisca Veyta Ayu
AU  - Fadli Jazaldi
AU  - Elza Ibrahim Auerkari
PY  - 2022
DA  - 2022/12/22
TI  - The Roles of Genetic and Epigenetic Aspects in Mandibular Prognathism: A Review
BT  - Proceedings of the 4th International Conference on Life Sciences and Biotechnology (ICOLIB 2021)
PB  - Atlantis Press
SP  - 277
EP  - 287
SN  - 2468-5747
UR  - https://doi.org/10.2991/978-94-6463-062-6_27
DO  - 10.2991/978-94-6463-062-6_27
ID  - Zahro2022
ER  -