Effectiveness Test of Red Ginger Extract (Zingiber Officinale var. Rubrum) on Blood Glucose Levels and Kidney Histopathology of Wistar Rats Induced by Streptozotocin

DOI

10.2991/978-94-6463-962-9_30How to use a DOI?

Keywords

Red Ginger; Histopatology; Blood Glucose Level

Abstract

Diabetes mellitus is a chronic metabolic condition characterized by high blood sugar levels caused by reduced insulin production, reduced response to insulin, or both [1]. Many traditional plants can lower blood sugar levels, but their use is often based solely on experience without sufficient clinical research support [2]. One plant known to lower blood sugar is red ginger. Red ginger has advantages in safety, practicality, and better economic aspects compared to frequently used chemical drugs [3]. To find out that the extract of red ginger (Zingiber officinale var. Rubrum) on blood glucose levels and kidney histopathology in streptozotocin-induced, this study used laboratory experimental method with a research design of Post Test Only Control Group Design. In this study, there were 40 male rats divided into 6 groups, with a negative control group (rats induced CMC Na 0,5%), a positive control group (rats induced with glibenklamid 20 mg/kgBW), a treatment group of rats induced with extract of red ginger used two different solutions, ethanol and n-hexane with doses of 80 mg/kgBW, 100 mg/kgBW, and 200 mg/kgBW respectively. Conclusion : red ginger extract (Zingiber officinale var. Rubrum) had an significant effect on blood glucose level and show a effect of improvement in kidney structure.

Copyright

© 2025 The Author(s)

Open Access

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TY  - CONF
AU  - Sri Lestari Ramadhani Nasution
AU  - Amelia Salsabila Purba
AU  - Tamarin Tamarin
AU  - Suhartina Suhartina
PY  - 2026
DA  - 2026/01/02
TI  - Effectiveness Test of Red Ginger Extract (Zingiber Officinale var. Rubrum) on Blood Glucose Levels and Kidney Histopathology of Wistar Rats Induced by Streptozotocin
BT  - Proceedings of the 2nd International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2025)
PB  - Atlantis Press
SP  - 299
EP  - 309
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-962-9_30
DO  - 10.2991/978-94-6463-962-9_30
ID  - Nasution2026
ER  -