Candidate IL-2 -330 T/G Polymorphism in Javanese with Schizophrenia

DOI

10.2991/978-94-6463-120-3_6How to use a DOI?

Keywords

schizophrenia; polymorphism; interleukin-2; Javanese; healthy control

Abstract

Background: Schizophrenia is a complex disorder involving multiple genes with mild to moderate effects and non-genetic risk factors such as environmental and psychological influences. A significant reduction in interleukin-2 -330 T/G production by peripheral lymphocytes is an immunological finding replicated in various countries. A study of interleukin-2 –330 T/G polymorphism in schizophrenic patients is still very limited and conducted in a few countries with different results. A study comparing interleukin-2 –330 T/G polymorphisms in Javanese with schizophrenia and healthy controls has also not been completed in Indonesia, particularly in North Sumatra Province.

Method: Sampling was performed using the non-probability purposive method. A total of 120 Javanese cases with schizophrenia and 120 healthy control at Prof. RSJ. M. Ildrem Medan, Indonesia, were recruited. The interleukin-2 -330 T/G polymorphism was examined by the PCR method.

Result: The genotype frequency of Javanese cases was 23.3% for GG, 44.2% for TG, and 32.5% for TT. The healthy control group’s GG, TG, and TT genotypes were 35%, 27.5% and 37.5%, respectively. The OR comparison to the GG and TG genotypes was 0.611 (95% CI 0.276–1.352, p = 0.224) and 0.892 (95% CI 0.505–1.574, p = 0.693). Furthermore, T allele was higher than G allele and healthy control, respectively (p = 0.229, OR = 0.813 (95% CI of 0.581- 1.218)).

Conclusion: There was no significant difference between the frequency of allele occurrence in Javanese cases with schizophrenia and healthy control. In addition, there was no significant relationship between the GG and TG genotypes of the interleukin-2 – 330T/G polymorphism and healthy control.

Copyright

© 2023 The Author(s)

Open Access

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TY  - CONF
AU  - Sutan Dassep Purnama
AU  - Mustafa M. Amin
AU  - Elmeida Effendy
PY  - 2023
DA  - 2023/03/31
TI  - Candidate IL-2 -330 T/G Polymorphism in Javanese with Schizophrenia
BT  - Proceedings of the 5th International Conference on Neuroscience, Neurology and Psychiatry (ICONAP 2022)
PB  - Atlantis Press
SP  - 39
EP  - 46
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-120-3_6
DO  - 10.2991/978-94-6463-120-3_6
ID  - Purnama2023
ER  -