Performance Optimization and Recovery: Molecular Docking Validation of Indonesian Herbal Compounds for Mitigating Physiological Fatigue in Athletes

DOI

10.2991/978-2-38476-591-1_4How to use a DOI?

Keywords

Exercise-induced fatigue; Molecular docking; Indonesian herbal compounds; Jamu; Athletic performance; Recovery; Anti-fatigue mechanisms

Abstract

Exercise-induced fatigue remains a critical factor limiting athletic performance and recovery. Indonesia’s phytopharmaceutical tradition, particularly Jamu, represents a valuable source of bioactive compounds with potential anti-fatigue properties. This study presents a systematic scientific review combined with in silico molecular docking analysis to examine the mechanisms underlying the anti-fatigue effects of selected Indonesian herbal compounds. The review synthesizes current evidence on the pathophysiology of fatigue, including metabolic, oxidative, inflammatory, and neurophysiological pathways, and identifies key medicinal plants such as Curcuma longa, Zingiber officinale, Centella asiatica, and Andrographis paniculata. Major bioactive constituents, including curcumin, gingerol, asiaticoside, and andrographolide, were evaluated for their binding interactions with fatigue-related protein targets. Molecular docking results revealed strong binding affinities (−7.6 to −9.5 kcal/mol) toward key regulators such as TNF-α, Keap1, AMPK, and 5-HT1A. These interactions indicate multiple complementary mechanisms, including modulation of inflammatory responses, attenuation of oxidative stress, regulation of energy metabolism, and stabilization of neurotransmitter activity. The findings highlight the potential of Indonesian herbal compounds as evidence-based candidates for the development of functional nutraceuticals aimed at enhancing athletic performance and accelerating recovery. This integrative approach strengthens the scientific foundation for the application of traditional herbal medicine within contemporary sport science.

Copyright

© 2026 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Armansyah Maulana Harahap
AU  - Yulia Putri
AU  - Herviani Sari
AU  - Muhammad Aldi Rivai Ginting
PY  - 2026
DA  - 2026/06/24
TI  - Performance Optimization and Recovery: Molecular Docking Validation of Indonesian Herbal Compounds for Mitigating Physiological Fatigue in Athletes
BT  - Proceedings of the 2nd International Conference of Sport Science, Sport Coaching Science, and Physical Education, and Recreation 2025 (ICOSSCOPER 2025)
PB  - Atlantis Press
SP  - 36
EP  - 48
SN  - 2352-5398
UR  - https://doi.org/10.2991/978-2-38476-591-1_4
DO  - 10.2991/978-2-38476-591-1_4
ID  - Harahap2026
ER  -