Proceedings of the 2nd International Conference on Veterinary, Animal, and Environmental Sciences (ICVAES 2020)

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Decreasing Blood Glucose Levels Using Muntingia calabura L. Leaf Extract in Rats with Diabetes Mellitus

Authors
Nurlena Andalia, M. Nur Salim, Nurdin, Ummu Balqis
Corresponding Author
Ummu Balqis
Available Online 21 April 2021.
DOI
10.2991/absr.k.210420.038How to use a DOI?
Keywords
blood glucose level, hyperglycemic, Muntingia calabura leaf extract, rat
Abstract

The aim of this study was to determine the decrease in blood glucose levels using Muntingia calabura L. leaf extract in hyperglycemic rats. This study used a completely randomized design with six treatments and four replications. The experimental animal used 24 male rats (Rattus novergicus) aged 3 months, body weight 200-250 grams. Group P1 as a negative control was only given distilled water. All rats in the P2, P3, P4, P5, P6 groups were induced with a single dose of alloxan 75 mg/kg body weight. Groups P3, P4, P5 were given 150, 300 and 450 mg/kg body weight of Muntingia calabura L. leaf extract and P6 were given metformin (positive control) for 28 days. The results showed that the mean glucose levels at P1, P2, P3, P4, P5, P6 were 59.75 ± 7.67, respectively; 151.75 ± 17.03; 83.25 ± 26.46; 74.5 ± 25.27; 72.5 ± 31.77; 69.5 ± 7.04. Based on Anova, Muntingia calabura L. leaf extract had a very significant effect on the blood glucose levels of rats (P <0.01). It can be concluded that Muntingia calabura L. leaf extract 450 mg/kg BW can reduce blood glucose levels in hyperglycemic rats.

Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2nd International Conference on Veterinary, Animal, and Environmental Sciences (ICVAES 2020)
Series
Advances in Biological Sciences Research
Publication Date
21 April 2021
ISBN
10.2991/absr.k.210420.038
ISSN
2468-5747
DOI
10.2991/absr.k.210420.038How to use a DOI?
Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Nurlena Andalia
AU  - M. Nur Salim
AU  - Nurdin
AU  - Ummu Balqis
PY  - 2021
DA  - 2021/04/21
TI  - Decreasing Blood Glucose Levels Using Muntingia calabura L. Leaf Extract in Rats with Diabetes Mellitus
BT  - Proceedings of the 2nd International Conference on Veterinary, Animal, and Environmental Sciences (ICVAES 2020)
PB  - Atlantis Press
SP  - 179
EP  - 183
SN  - 2468-5747
UR  - https://doi.org/10.2991/absr.k.210420.038
DO  - 10.2991/absr.k.210420.038
ID  - Andalia2021
ER  -