Identification of MSX1 Mutation in Malaysian Hypodontia Family
Nabilah Muhamad Zamil, Nor Aini Mohamed Yussof, Yunita Dewi Ardini, Widya Lestari
Nabilah Muhamad Zamil
Available Online February 2018.
- https://doi.org/10.2991/idcsu-17.2018.49How to use a DOI?
- MSX1, mutation, hypodontia
- Hypodontia is defined as the absence of one to six teeth. There is high prevalence of hypodontia recorded in Malaysia (2.8%). This study aimed to identify any mutation of MSX1 in Malaysian family with hypodontia and its clinical finding. We re-examined 4 individuals from a family of the previous PAX9 study. Orthophantomogram (OPG) and intraoral photos were re-assessed. Saliva was collected for genetic analysis. Direct sequencing was done on exons 1 and 2 of MSX1. 2 out of 4 members (1A and 1D) in the family have anterior hypodontia. Point mutation on exon1 of MSX1 (c.731G>A) was observed in 1A (father) with missing 13 and 23 and 1C (carrier-son). c.732G>A was found on exon1 of MSX1 of his daughter (1D) with missing 32.MSX1 mutation is involved in the occurrence of hypodontia in patient.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Nabilah Muhamad Zamil AU - Nor Aini Mohamed Yussof AU - Yunita Dewi Ardini AU - Widya Lestari PY - 2018/02 DA - 2018/02 TI - Identification of MSX1 Mutation in Malaysian Hypodontia Family PB - Atlantis Press SP - 183 EP - 185 SN - 2468-5739 UR - https://doi.org/10.2991/idcsu-17.2018.49 DO - https://doi.org/10.2991/idcsu-17.2018.49 ID - MuhamadZamil2018/02 ER -