Proceedings of the International Dental Conference of Sumatera Utara 2017 (IDCSU 2017)

Identification of MSX1 Mutation in Malaysian Hypodontia Family

Authors
Nabilah Muhamad Zamil, Nor Aini Mohamed Yussof, Yunita Dewi Ardini, Widya Lestari
Corresponding Author
Nabilah Muhamad Zamil
Available Online February 2018.
DOI
https://doi.org/10.2991/idcsu-17.2018.49How to use a DOI?
Keywords
MSX1, mutation, hypodontia
Abstract
Hypodontia is defined as the absence of one to six teeth. There is high prevalence of hypodontia recorded in Malaysia (2.8%). This study aimed to identify any mutation of MSX1 in Malaysian family with hypodontia and its clinical finding. We re-examined 4 individuals from a family of the previous PAX9 study. Orthophantomogram (OPG) and intraoral photos were re-assessed. Saliva was collected for genetic analysis. Direct sequencing was done on exons 1 and 2 of MSX1. 2 out of 4 members (1A and 1D) in the family have anterior hypodontia. Point mutation on exon1 of MSX1 (c.731G>A) was observed in 1A (father) with missing 13 and 23 and 1C (carrier-son). c.732G>A was found on exon1 of MSX1 of his daughter (1D) with missing 32.MSX1 mutation is involved in the occurrence of hypodontia in patient.
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Proceedings
International Dental Conference of Sumatera Utara 2017 (IDCSU 2017)
Part of series
Advances in Health Sciences Research
Publication Date
February 2018
ISBN
978-94-6252-474-3
ISSN
2468-5739
DOI
https://doi.org/10.2991/idcsu-17.2018.49How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Nabilah Muhamad Zamil
AU  - Nor Aini Mohamed Yussof
AU  - Yunita Dewi Ardini
AU  - Widya Lestari
PY  - 2018/02
DA  - 2018/02
TI  - Identification of MSX1 Mutation in Malaysian Hypodontia Family
BT  - International Dental Conference of Sumatera Utara 2017 (IDCSU 2017)
PB  - Atlantis Press
SN  - 2468-5739
UR  - https://doi.org/10.2991/idcsu-17.2018.49
DO  - https://doi.org/10.2991/idcsu-17.2018.49
ID  - MuhamadZamil2018/02
ER  -