Anti-Diabetic Effect of Singi Fruit (Dillenia serrata) in Male Rats (Rattus novergicus) Induced with a High-Fat Diet

DOI

10.2991/978-94-6463-392-4_3How to use a DOI?

Keywords

Anti-diabetic; Blood Glucose Level; Dillenia serrata; High Fat Diet

Abstract

Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia that occurs due to defects in insulin secretion, insulin action, or both. Dyslipidemia is one of the risk factors for coronary heart disease and is often associated with diabetes mellitus. Statins are recommended by several guidelines as first-line treatment for lowering LDL levels and have been shown to be beneficial in primary and secondary prevention to reduce cardiovascular disease morbidity and mortality in high-risk patients. The usage of medications made from natural substances can be an alternative therapy that lessens the adverse effects brought on by the use of synthetic drugs. In vitro studies related to the potential of singi fruit (D. serrata) in inhibiting the activation of HMG CoA reductase and the presence of flavonoids as antioxidants that are protective against cell damage as well as insulin-producing and can increase insulin sensitivity This study used a quasi-experimental in vivo design with a pre- and post-test only control group design, with the independent variable being the feeding of singi fruit meat (D. serrata) and the dependent variable being blood glucose levels in male white rats of the Wistar strain (Rattus novergicus), which were divided into 4 groups, i.e. the healthy rat group, High Fat diet (HFD) group, singi group, and simvastatin group. The results of this study revealed a significant effect on blood glucose levels in rats induced by a high-fat diet in groups: HFD group (0.017), D. serrata group (0.011), and simvastatin group (0.002), significant with a p value < 0.05, and significant differences between groups: healthy group, HFD group, D. serrata group, and simvastatin group with a p value 0.05).There was a significant effect of feeding singi fruit meat (D. serrata) on the blood glucose levels of rats induced with a high-fat diet.

Copyright

© 2024 The Author(s)

Open Access

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TY  - CONF
AU  - A. Pranita
AU  - T. Tien
AU  - A. Arimaswati
AU  - U. Ainun
PY  - 2024
DA  - 2024/04/22
TI  - Anti-Diabetic Effect of Singi Fruit (Dillenia serrata) in Male Rats (Rattus novergicus) Induced with a High-Fat Diet
BT  - Proceedings of the 1st International Conference Medical and Health Science Halu Oleo (IMHO 2023)
PB  - Atlantis Press
SP  - 22
EP  - 32
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-392-4_3
DO  - 10.2991/978-94-6463-392-4_3
ID  - Pranita2024
ER  -