Proceedings of the 2016 International Conference on Innovative Material Science and Technology (IMST 2016)

Facile way of surface modification on hydrogel for drug delivery

Authors
Xin Wang, Pin Chen, Xiaohong Hu
Corresponding Author
Xin Wang
Available Online November 2016.
DOI
10.2991/imst-16.2016.5How to use a DOI?
Keywords
surface modification; hydrogel; drug delivery; ß-cyclodextrin (ß-CD).
Abstract

Although hydrogel has some outstanding performance, traditional hydrogel still has some drawbacks in the application of drug delivery field. Herein, we introduced a simple and effective way to improve the performance of tradition hydrogel for drug delivery. ß-cyclodextrin (ß-CD) functionized hydrogel was acquired through a two-step facile way, that is, alkaline hydrolysis and epichlorohydrin crosslinking. Though the reaction ratio of alkaline hydrolysis and the grafting ratio of ß-CD varied slightly according different detection methods, successful modification as well as proper properties including contact angle, equilibrium water content and surface morphology was still approved through the results of this work. The equilibrium amount of loading orfloxacin in hydrogels increased significantly with the increase of drug concentration and the equilibrium amount of loading orfloxacin in ß-CD modified hydrogel was superior to that in traditional hydrogel with significant difference. The loading drug concentration as well as ß-CD had effects on drug release behaviors.

Copyright
© 2016, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2016 International Conference on Innovative Material Science and Technology (IMST 2016)
Series
Advances in Intelligent Systems Research
Publication Date
November 2016
ISBN
10.2991/imst-16.2016.5
ISSN
1951-6851
DOI
10.2991/imst-16.2016.5How to use a DOI?
Copyright
© 2016, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Xin Wang
AU  - Pin Chen
AU  - Xiaohong Hu
PY  - 2016/11
DA  - 2016/11
TI  - Facile way of surface modification on hydrogel for drug delivery
BT  - Proceedings of the 2016 International Conference on Innovative Material Science and Technology (IMST 2016)
PB  - Atlantis Press
SP  - 35
EP  - 41
SN  - 1951-6851
UR  - https://doi.org/10.2991/imst-16.2016.5
DO  - 10.2991/imst-16.2016.5
ID  - Wang2016/11
ER  -