Histopathological Changes and Harmful Effects of Garamycin (60) Mg by Intramuscular Injection in Experimental White Rats

DOI

10.2991/ahsr.k.211012.007How to use a DOI?

Keywords

Garamycin, Hepatopathy, Nephropathy, clinical findings

Abstract

This study has shown the effects of gentamicin sulfate injection (60 mg/kg/b.w.) in thigh muscle for two months twice daily (morning and evening) on the histological structure of the kidneys, liver and cardiac muscle of rats. Vacuolation, dilatated cortical tubules and degeneration, necrosis of proximal convoluted tubules were seen in the treated group. Congestion, cardiac muscle vacuolation as well as hepatocytes degeneration and sinusoids congestion with obvious bile duct proliferation were also seen. Through our studies showed clinical findings such as anorexia and subsequent emaciation and certain animals were presumably killed in the treatment group due to gentamicin caused renal failure.

Copyright

© 2021, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

TY  - CONF
AU  - Mohammed A. Hassan
AU  - Lamya M. Shaker
AU  - Aliaa A. Hammouda
PY  - 2021
DA  - 2021/10/12
TI  - Histopathological Changes and Harmful Effects of Garamycin (60) Mg by Intramuscular Injection in Experimental White Rats
BT  - Proceedings of the 1st International Ninevah Conference on Medical Sciences (INCMS 2021)
PB  - Atlantis Press
SP  - 38
EP  - 46
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.211012.007
DO  - 10.2991/ahsr.k.211012.007
ID  - Hassan2021
ER  -