Procalcitonin in Children with Relapsing Steroid- Sensitivenephrotic SyndromeA 14-year Retrospective Study

DOI

10.2991/isphe-18.2018.62How to use a DOI?

Keywords

procalcitonin, minimal change nephropathy, steroid-sensitive nephrotic syndrome, children, relapse

Abstract

Abstract—Sensitive-Steroid Nephrotic Syndrome (SSNS) is the most common chronic glomerular disease in children with high incidence of relapse. Infections were statistically significant risk factors for recurrence in SSNS. Current findings suggest that procalcitonin (PCT) may not only be a valid marker for infection and inflammation but also a pro-inflammatory cytokine-like mediator. To identify the relationship betweenprocalcitonin and relapse in childhood SSNS. A crosssectional study was conducted from February 2017 to February 2018. Complete blood count, procalcitonin, and urinalysiswere obtained. Data wasanalyzed by chi-square test with P-value <0.05 considered significant. Of all 55 samples, the percentage of relapsing SSNS in this study is 72.7%. On Receiver Operating Characteristic(ROC) curve, the total Area Under Curve (AUC) was 73.6% with P = 0.007. There was a statistically significant correlation between procalcitonin level cut off 0.065 ng / dL with relapse occurrence (P value = 0.002), with a prevalence ratio of8.308 (CI :95% range: 1.993-34.636). Procalcitonin with cut off value > 0.065 ng / dl gave the best accuracy (70.9%), which predicted relapse with sensitivity 67.5%, specificity 80%. The occurrence of relapsingnephrotic syndrome is influenced only with procalcitonin in this study.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Dian Ismawardani
AU  - Oke Rina Ramayani
AU  - Yazid Dimyati
AU  - Zulfikar Lubis
AU  - Atan Baas Sinuhaji
AU  - Rita Evalina
PY  - 2018/05
DA  - 2018/05
TI  - Procalcitonin in Children with Relapsing Steroid- Sensitivenephrotic SyndromeA 14-year Retrospective Study
BT  - Proceedings of the International Seminar on Public Health and Education 2018 (ISPHE 2018)
PB  - Atlantis Press
SP  - 267
EP  - 270
SN  - 2468-5739
UR  - https://doi.org/10.2991/isphe-18.2018.62
DO  - 10.2991/isphe-18.2018.62
ID  - Ismawardani2018/05
ER  -