Proceedings of the 2015 International Conference on Industrial Technology and Management Science

Novel Nitro Derivatives of Benzothiadiazine 1,1-Dioxide as Aldose Reductase Inhibitors

Authors
Shaoqi Yang, Xiangyu Qin, Tianwei Luo, Xin Hao, Changjin Zhu
Corresponding Author
Shaoqi Yang
Available Online November 2015.
DOI
https://doi.org/10.2991/itms-15.2015.260How to use a DOI?
Keywords
Nitro compound; benzothiadiazine 1,1-dioxide; aldose reductase inhibitor
Abstract
Novel nitro-benzothiadiazine 1,1-dioxide derivatives were synthesized and tested for their inhibitory activity against aldose reductase. Of them, 5-nitro and 8-nitro bearing ones displayed significant activity in IC50 values of 4.6 and 13.45µM. Their docking behaviors were also studied.
Open Access
This is an open access article distributed under the CC BY-NC license.

Download article (PDF)

Proceedings
2015 International Conference on Industrial Technology and Management Science
Part of series
Advances in Computer Science Research
Publication Date
November 2015
ISBN
978-94-6252-123-0
ISSN
2352-538X
DOI
https://doi.org/10.2991/itms-15.2015.260How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Shaoqi Yang
AU  - Xiangyu Qin
AU  - Tianwei Luo
AU  - Xin Hao
AU  - Changjin Zhu
PY  - 2015/11
DA  - 2015/11
TI  - Novel Nitro Derivatives of Benzothiadiazine 1,1-Dioxide as Aldose Reductase Inhibitors
BT  - 2015 International Conference on Industrial Technology and Management Science
PB  - Atlantis Press
SN  - 2352-538X
UR  - https://doi.org/10.2991/itms-15.2015.260
DO  - https://doi.org/10.2991/itms-15.2015.260
ID  - Yang2015/11
ER  -