Novel Nitro Derivatives of Benzothiadiazine 1,1-Dioxide as Aldose Reductase Inhibitors

DOI

10.2991/itms-15.2015.260How to use a DOI?

Keywords

Nitro compound; benzothiadiazine 1,1-dioxide; aldose reductase inhibitor

Abstract

Novel nitro-benzothiadiazine 1,1-dioxide derivatives were synthesized and tested for their inhibitory activity against aldose reductase. Of them, 5-nitro and 8-nitro bearing ones displayed significant activity in IC50 values of 4.6 and 13.45µM. Their docking behaviors were also studied.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Shaoqi Yang
AU  - Xiangyu Qin
AU  - Tianwei Luo
AU  - Xin Hao
AU  - Changjin Zhu
PY  - 2015/11
DA  - 2015/11
TI  - Novel Nitro Derivatives of Benzothiadiazine 1,1-Dioxide as Aldose Reductase Inhibitors
BT  - Proceedings of the 2015 International Conference on Industrial Technology and Management Science
PB  - Atlantis Press
SP  - 1077
EP  - 1080
SN  - 2352-538X
UR  - https://doi.org/10.2991/itms-15.2015.260
DO  - 10.2991/itms-15.2015.260
ID  - Yang2015/11
ER  -