Synthesis of tert-butyl 4-((2-methoxy-4-(methoxycarbonyl) phenoxy) methyl) piperidine-1-carboxylate

DOI

10.2991/iwmecs-15.2015.46How to use a DOI?

Keywords

tert-butyl 4-((2-methoxy-4-(methoxycarbonyl) phenoxy) methyl) piperidine-1- carboxylate; Vandetanib; Synthesis.

Abstract

Tert-butyl 4-((2-methoxy-4-(methoxycarbonyl) phenoxy) methyl) piperidine-1-carboxylate (1) is the key intermediate of Vandetanib. It was synthesized from piperidin-4-ylmethanol (2) through three steps Including acylation, sulfonation and substitution. The structures and the synthetic route were determined by MS and 1HNMR.And the synthetic method was optimized. The total yield of the three steps was 20.2%.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Min Wang
AU  - Wenhui Wang
AU  - Qidong Tang
AU  - Shan Xu
PY  - 2015/10
DA  - 2015/10
TI  - Synthesis of tert-butyl 4-((2-methoxy-4-(methoxycarbonyl) phenoxy) methyl) piperidine-1-carboxylate
BT  - Proceedings of the 2015 2nd International Workshop on Materials Engineering and Computer Sciences
PB  - Atlantis Press
SP  - 243
EP  - 245
SN  - 2352-538X
UR  - https://doi.org/10.2991/iwmecs-15.2015.46
DO  - 10.2991/iwmecs-15.2015.46
ID  - Wang2015/10
ER  -