Lipase Catalyzed Naproxen Methyl Ester Enantioselective Hydrolysis in Ionic Liquids
Authors
Shengbo Gao, Quanhui Li, Tingting Yao, Zhengyang Wang, Luoyun Zheng, Jiaying Xin
Corresponding Author
Shengbo Gao
Available Online December 2016.
- DOI
- 10.2991/mcei-16.2016.4How to use a DOI?
- Keywords
- Lipase; Enantioselective hydrolysis; Naproxen; Ionic liquids; Biphasic system
- Abstract
A series of dialkylimidazolium ionic liquids with various anions including hexafluorophosphate alkane sulfonate and tetrafluoroborates were studied in the lipase-catalyzed enantioselective hydrolysis. Lipase activity,stability and enantioselectivity were determined by both of alkane and anions. In the best aqueous- C4mimPF6 biphasic system lipase resolution of Naproxen proceed with much effective. It was observed that the activity of lipase in aqueous- C4mimPF6 system was comparable with that in aqueous-organic system, but the enantiomeric ratio of Lipase-catalysis hydrolysis in aqueous - C4mimPF6 biphasic system (E>300) was much higher than that in aqueous -organic biphasic system (E 90).
- Copyright
- © 2017, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Shengbo Gao AU - Quanhui Li AU - Tingting Yao AU - Zhengyang Wang AU - Luoyun Zheng AU - Jiaying Xin PY - 2016/12 DA - 2016/12 TI - Lipase Catalyzed Naproxen Methyl Ester Enantioselective Hydrolysis in Ionic Liquids BT - Proceedings of the 2016 6th International Conference on Mechatronics, Computer and Education Informationization (MCEI 2016) PB - Atlantis Press SP - 14 EP - 17 SN - 1951-6851 UR - https://doi.org/10.2991/mcei-16.2016.4 DO - 10.2991/mcei-16.2016.4 ID - Gao2016/12 ER -