Proceedings of the 2016 6th International Conference on Mechatronics, Computer and Education Informationization (MCEI 2016)

Lipase Catalyzed Naproxen Methyl Ester Enantioselective Hydrolysis in Ionic Liquids

Authors
Shengbo Gao, Quanhui Li, Tingting Yao, Zhengyang Wang, Luoyun Zheng, Jiaying Xin
Corresponding Author
Shengbo Gao
Available Online December 2016.
DOI
https://doi.org/10.2991/mcei-16.2016.4How to use a DOI?
Keywords
Lipase; Enantioselective hydrolysis; Naproxen; Ionic liquids; Biphasic system
Abstract
A series of dialkylimidazolium ionic liquids with various anions including hexafluorophosphate alkane sulfonate and tetrafluoroborates were studied in the lipase-catalyzed enantioselective hydrolysis. Lipase activity,stability and enantioselectivity were determined by both of alkane and anions. In the best aqueous- C4mimPF6 biphasic system lipase resolution of Naproxen proceed with much effective. It was observed that the activity of lipase in aqueous- C4mimPF6 system was comparable with that in aqueous-organic system, but the enantiomeric ratio of Lipase-catalysis hydrolysis in aqueous - C4mimPF6 biphasic system (E>300) was much higher than that in aqueous -organic biphasic system (E 90).
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Proceedings
2016 6th International Conference on Mechatronics, Computer and Education Informationization (MCEI 2016)
Part of series
Advances in Intelligent Systems Research
Publication Date
December 2016
ISBN
978-94-6252-282-4
ISSN
1951-6851
DOI
https://doi.org/10.2991/mcei-16.2016.4How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Shengbo Gao
AU  - Quanhui Li
AU  - Tingting Yao
AU  - Zhengyang Wang
AU  - Luoyun Zheng
AU  - Jiaying Xin
PY  - 2016/12
DA  - 2016/12
TI  - Lipase Catalyzed Naproxen Methyl Ester Enantioselective Hydrolysis in Ionic Liquids
BT  - 2016 6th International Conference on Mechatronics, Computer and Education Informationization (MCEI 2016)
PB  - Atlantis Press
SN  - 1951-6851
UR  - https://doi.org/10.2991/mcei-16.2016.4
DO  - https://doi.org/10.2991/mcei-16.2016.4
ID  - Gao2016/12
ER  -