Proceedings of the 2015 International Conference on Materials, Environmental and Biological Engineering

Manganese-Induced Effects on Calcium Homeostasis of the Neurons in Hyline Cocks

Authors
Xiaofei Liu, Lirong Jing, Lv Xue, Yongqiang Ma, Huanan Guan, Wang Wei
Corresponding Author
Xiaofei Liu
Available Online April 2015.
DOI
10.2991/mebe-15.2015.34How to use a DOI?
Keywords
Manganese; Calcium Homeostasis; Neurons; Cocks
Abstract

Manganese (Mn) is known to be essential for maintaining the proper function and regulation of many biochemical. To investigate the toxicity of Mn on bird brains, 50-day-old cocks were fed either a commercial diet or a Mn-supplemented diet. the following were determined: Mn concentration, Ca2+ concentration, the expression of Calmodulin (CaM) and Calcineurin (CaN) gene. Exposure to Mn significantly lowered expression of CaM and CaN gene. However, Mn was accumulated in brain and the Ca2+ concentration was increased. These findings suggested that Mn exposure resulted in the damage of cock cerebral tissue by altering calcium homeostasis, which are possible underlying neurotoxicity mechanisms.

Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2015 International Conference on Materials, Environmental and Biological Engineering
Series
Advances in Engineering Research
Publication Date
April 2015
ISBN
978-94-62520-57-8
ISSN
2352-5401
DOI
10.2991/mebe-15.2015.34How to use a DOI?
Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Xiaofei Liu
AU  - Lirong Jing
AU  - Lv Xue
AU  - Yongqiang Ma
AU  - Huanan Guan
AU  - Wang Wei
PY  - 2015/04
DA  - 2015/04
TI  - Manganese-Induced Effects on Calcium Homeostasis of the Neurons in Hyline Cocks
BT  - Proceedings of the 2015 International Conference on Materials, Environmental and Biological Engineering
PB  - Atlantis Press
SP  - 139
EP  - 142
SN  - 2352-5401
UR  - https://doi.org/10.2991/mebe-15.2015.34
DO  - 10.2991/mebe-15.2015.34
ID  - Liu2015/04
ER  -