Proceedings of the 2015 International Conference on Materials, Environmental and Biological Engineering

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Research on Non-linear Relationship among Histone Modifications in Yeast Genome

Authors
Panfeng Chen, JiHua Feng, Zenhui Shan, Henhen Wei, Huan Hu
Corresponding Author
Panfeng Chen
Available Online April 2015.
DOI
10.2991/mebe-15.2015.102How to use a DOI?
Keywords
Histone modification; Pearson Correlation; MINE.
Abstract

In the process of we studied chromosome modifications, we found the previous studies only focused on linear relationship between chemical modifications. So we interfered the data sets of the Yeast histone Methylation modification and Acetylation which are measured by Pothook et al. We got 16 kinds of protein modification date sets in the whole genome. Then we processed the each of data sets by aligning, averaging and normalizing data around the TSS (about 1000bp from upstream or downstream).After we grouped the whole genome histone modification data sets according to the Yeast genome transcription level data : one modified groups promote transcription, and the other modified groups inhibit transcription or are independent of transcription. In order to reveal the complex relationships between different transcriptional activity of genetically modified, we calculated the correlation among several modifications with two by algorithms–Pearson correlation analysis and MINE proposed by David N. Reshelf et al. We analyzed the results and got some non-linear relationship between histone modifications. We also found that the association between histone modifications stronger in the same modified group.

Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2015 International Conference on Materials, Environmental and Biological Engineering
Series
Advances in Engineering Research
Publication Date
April 2015
ISBN
10.2991/mebe-15.2015.102
ISSN
2352-5401
DOI
10.2991/mebe-15.2015.102How to use a DOI?
Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Panfeng Chen
AU  - JiHua Feng
AU  - Zenhui Shan
AU  - Henhen Wei
AU  - Huan Hu
PY  - 2015/04
DA  - 2015/04
TI  - Research on Non-linear Relationship among Histone Modifications in Yeast Genome
BT  - Proceedings of the 2015 International Conference on Materials, Environmental and Biological Engineering
PB  - Atlantis Press
SP  - 433
EP  - 437
SN  - 2352-5401
UR  - https://doi.org/10.2991/mebe-15.2015.102
DO  - 10.2991/mebe-15.2015.102
ID  - Chen2015/04
ER  -