Effects of Current Pacing and Electrical Field on The Turbulence Induced by Voltage Oscillations in Hearts
Hong Zhang, Ruijuan Li, Dan Zhao, Yuan Liu
Available Online August 2015.
- https://doi.org/10.2991/msam-15.2015.8How to use a DOI?
- turbulence; current pacing; electrical field; action potential mathematical model; computer simulations
- To the turbulence induced by local voltage oscillations during repolarizing phase of the cardiac action potential, the effects of current pacing and electrical field were investigated to reveal their feasibilities in elimination of the turbulence. A local pathological 2-dimensional tissue including 401 × 401 myocytes was developed on the basis of LR91 single cell mathematical model. The myocytes at the central 20 × 20 region was characterized with voltage oscillations by increasing time constant of K+ gating variable and maximum conductance of Ca2+ current. The cross field method was used to induce spiral waves that degraded to turbulence-like fibrillation under the influence of pathological region. The defibrillation model was created by introducing the current and electrical field terms, respectively. The computer simulation results showed that local current pacing had no significant effects on the turbulence, but after subsequent application of electrical field, the turbulence was depressed around 240 ms. Current pacing on the whole tissue was able to completely suppress wave breakup at 625 ms, but with the execution of electrical field, the elimination time reduced to 240 ms. Therefore, current pacing together with electrical field has greater effects on electrical activities of the tissue. It promotes the process to suppress the wave breakup, thus eliminating the turbulence-like fibrillation.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Hong Zhang AU - Ruijuan Li AU - Dan Zhao AU - Yuan Liu PY - 2015/08 DA - 2015/08 TI - Effects of Current Pacing and Electrical Field on The Turbulence Induced by Voltage Oscillations in Hearts BT - 2015 International Conference on Modeling, Simulation and Applied Mathematics PB - Atlantis Press SN - 1951-6851 UR - https://doi.org/10.2991/msam-15.2015.8 DO - https://doi.org/10.2991/msam-15.2015.8 ID - Zhang2015/08 ER -