Simulation and On-line Real-time Measurement of Aspirin Crystalline Particle Size Distribution Based on Ultrasound
San Xu, Xiuxi Li
Available Online March 2017.
- https://doi.org/10.2991/msam-17.2017.15How to use a DOI?
- ultrasound; crystallization; measurement; simulation; particle size distribution
- Ultrasound is a new method in the measurement of a crystallization process. The cooling crystallization of Aspirin in ethanol is investigated vias experiments and population balance model. The particle size distribution of the crystallization is monitored online by ultrasonic attenuation spectroscopy. Solubility is measured in situ by the Attenuated Total Reflectance Fourier Transform Infrared. The crystallization kinetics of the Aspirin is studied based on crystallization experiments by a combination of a population balance model and a multiple linear least square method. The results show that the measured value is in good consistent with the simulated value. This proves high feasibility and reliability of ultrasound in the measurement of the crystallization process.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - San Xu AU - Xiuxi Li PY - 2017/03 DA - 2017/03 TI - Simulation and On-line Real-time Measurement of Aspirin Crystalline Particle Size Distribution Based on Ultrasound BT - 2017 2nd International Conference on Modelling, Simulation and Applied Mathematics (MSAM2017) PB - Atlantis Press SP - 57 EP - 63 SN - 1951-6851 UR - https://doi.org/10.2991/msam-17.2017.15 DO - https://doi.org/10.2991/msam-17.2017.15 ID - Xu2017/03 ER -