Screening and Analysis of lncRNA Biomarkers and the Relationship with the Corresponding Regulatory miRNA for Progressive Acute Lymphoblastic Leukemia

DOI

10.2991/msbda-19.2019.51How to use a DOI?

Keywords

TARGET, Acute lymphoblastic leukaemia, ROC, Medical big data analysis, C20orf166-AS1, Progressive biomarker

Abstract

In this study, we aim to find out the lncRNA biomarker of progressive acute lymphoblastic leukaemia (ALL). After the comparison of the phase II and phase III gene expression downloaded from Therapeutically Applicable Research to Generate Effective Treatment (TARGET) online database, 112 differentially expressed lncRNAs and 73 differentially expressed miRNAs were screened by edge R package. The regulatory of lncRNA-miRNA was found based on the screened differentially expressed gene by using the mircode database. C20orf166-AS1 was analyzed as a new progressive biomarker by comparing the gene expression in different tumors by cancer cell line encyclopedia website. And the impact on ALL progression was proven by the receiver operating characteristic (ROC) curve and kmplot survival curve.

Copyright

© 2019, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

TY  - CONF
AU  - Jianzhi Deng
AU  - Yuehan Zhou
AU  - Xiaohui Cheng
AU  - Mingjun Xu
PY  - 2019/08
DA  - 2019/08
TI  - Screening and Analysis of lncRNA Biomarkers and the Relationship with the Corresponding Regulatory miRNA for Progressive Acute Lymphoblastic Leukemia
BT  - Proceedings of the 2019 International Conference on Modeling, Simulation and Big Data Analysis (MSBDA 2019)
PB  - Atlantis Press
SP  - 332
EP  - 337
SN  - 2352-538X
UR  - https://doi.org/10.2991/msbda-19.2019.51
DO  - 10.2991/msbda-19.2019.51
ID  - Deng2019/08
ER  -