Proceedings of the 2nd Global Health and Innovation in conjunction with 6th ORL Head and Neck Oncology Conference (ORLHN 2021)

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Corelation Between Epstein Barr Virus Epstein Barr Nuclear Antigen 1 DNA with Nasopharyngeal Carcinoma in Minangkabau Ethnic

Authors
Desy Ambriani1, 2, *, Sukri Rahman1, 2, Al Hafiz1, 2, Hirowati Ali3, Hafni Bachtiar4
1Department of Otorhinolaryngology Head & Neck Surgery of Faculty Medicine Andalas University, Padang, Indonesia
2Dr. M. Djamil General Hospital, Padang, Indonesia
3Department of Biochemical Science of Faculty Medicine Andalas University, Padang, Indonesia
4Department of Public Health of Faculty Medicine Andalas University, Padang, Indonesia
*Corresponding author. Email: dr.DesyAmbriani@gmail.com
Corresponding Author
Desy Ambriani
Available Online 21 February 2022.
DOI
10.2991/ahsr.k.220206.018How to use a DOI?
Keywords
epstein barr nuclear antigen-1; nasopharyngeal carcinoma; Minangkabau
Abstract

Nasopharyngeal carcinoma (NFC) is a malignancy that come from the nasopharyngeal epithelial cell which is that distribution has been affected by geographic and ethnicity. NFC is caused by multifactorial causes, one of the is Epstein Barr Nuclear Antigen-1 (EBNA-1). EBNA-1 affects some of the signalling pathways, including cell proliferation, invasion, survival, and DNA Repair. This study aimed to know the correlation between EBV (EBNA-1) DNA with NFC incidence in Minangkabau Ethnicity. This study is analytic observational with a cross-sectional comparative study. Twenty-two plasmas of the NFC patients with Minangkabau ethnicity compared with 22 plasma of NPC patients with non-Minangkabau ethnicity as control, which matched their sex and age (±3 years). EBNA-1 level expression was checked with quantitative real-time PCR (qPCR) methods to check the DNA targeting EBNA-1 from the EBV genome. The data was then analyzed with Saphiro Wilk for normality and continued with the LG10 transformation test. They are then finalized with Mann-Whitney for the two groups. The average expression level of the EBNA-1 in NFC patients is higher than the control’s plasma in Minangkabau ethnicity but not statistically significant.

Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article under the CC BY-NC license.

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Volume Title
Proceedings of the 2nd Global Health and Innovation in conjunction with 6th ORL Head and Neck Oncology Conference (ORLHN 2021)
Series
Advances in Health Sciences Research
Publication Date
21 February 2022
ISBN
10.2991/ahsr.k.220206.018
ISSN
2468-5739
DOI
10.2991/ahsr.k.220206.018How to use a DOI?
Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article under the CC BY-NC license.

Cite this article

risenwbib
TY  - CONF
AU  - Desy Ambriani
AU  - Sukri Rahman
AU  - Al Hafiz
AU  - Hirowati Ali
AU  - Hafni Bachtiar
PY  - 2022
DA  - 2022/02/21
TI  - Corelation Between Epstein Barr Virus Epstein Barr Nuclear Antigen 1 DNA with Nasopharyngeal Carcinoma in Minangkabau Ethnic
BT  - Proceedings of the 2nd Global Health and Innovation in conjunction with 6th ORL Head and Neck Oncology Conference (ORLHN 2021)
PB  - Atlantis Press
SP  - 89
EP  - 92
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.220206.018
DO  - 10.2991/ahsr.k.220206.018
ID  - Ambriani2022
ER  -