Proceedings of the 2nd Global Health and Innovation in conjunction with 6th ORL Head and Neck Oncology Conference (ORLHN 2021)

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Correlation Between Interleukin 6 with Nasopharyngeal Carcinoma in the Minangkabau Ethnic Group

Authors
Rimelda Aquinas1, 2, *, Sukri Rahman1, 2, Al Hafiz1, 2, Hirowati Ali3, Hafni Bachtiar4
1Department of Otorhinolaryngology Head & Neck Surgery of Faculty Medicine Andalas University, Padang, Indonesia
2Dr. M. Djamil General Hospital, Padang, Indonesia
3Department of Biochemical Science of Faculty Medicine Andalas University, Padang, Indonesia
4Department of Public Health of Faculty Medicine Andalas University, Padang, Indonesia
*Corresponding author. Email: rimelaquinas51189@gmail.com
Corresponding Author
Rimelda Aquinas
Available Online 21 February 2022.
DOI
10.2991/ahsr.k.220206.013How to use a DOI?
Keywords
interleukin 6; nasopharyngeal cancer; Minangkabau
Abstract

Nasopharyngeal carcinoma (NPC) is a malignant tumour of nasopharyngeal epithelium that has a unique distribution pattern. Nasopharyngeal carcinoma is not only geographically specific but also ethnically. Some ethnic groups tend to suffer NPC. Multifactorial interactions are presumed to be the cause of NPC. One of them is interaction with interleukin 6 (IL-6). Interleukin 6 is a glycoprotein that not only links between chronic inflammation and progression of the tumour, but also a role as an important regulator to immune response and the growth factor of NPC. This study aimed to determine the correlation of IL-6 with NPC in the Minangkabau ethnic group. This study was an analytical study with a cross-sectional comparative study. A total of 21 plasma of NPC patients of the Minangkabau ethnic group and 21 plasma sex and aged-matched ±3 years controls participated in this study. Plasma IL-6 levels were measured with ELISA (Enzyme-Linked Immunosorbent Assay). All data were subjected to a normality test with Shapiro Wilk and a log 10 transformation test. Then performed an independent t-test in both groups. The plasma level of IL-6 in the NPC group was higher (46.16±73.10pg/ml) than the plasma control group (23.16±25.84pg/ml), but it was not statistically significant (p>0.05).

Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article under the CC BY-NC license.

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Volume Title
Proceedings of the 2nd Global Health and Innovation in conjunction with 6th ORL Head and Neck Oncology Conference (ORLHN 2021)
Series
Advances in Health Sciences Research
Publication Date
21 February 2022
ISBN
10.2991/ahsr.k.220206.013
ISSN
2468-5739
DOI
10.2991/ahsr.k.220206.013How to use a DOI?
Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article under the CC BY-NC license.

Cite this article

risenwbib
TY  - CONF
AU  - Rimelda Aquinas
AU  - Sukri Rahman
AU  - Al Hafiz
AU  - Hirowati Ali
AU  - Hafni Bachtiar
PY  - 2022
DA  - 2022/02/21
TI  - Correlation Between Interleukin 6 with Nasopharyngeal Carcinoma in the Minangkabau Ethnic Group
BT  - Proceedings of the 2nd Global Health and Innovation in conjunction with 6th ORL Head and Neck Oncology Conference (ORLHN 2021)
PB  - Atlantis Press
SP  - 62
EP  - 67
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.220206.013
DO  - 10.2991/ahsr.k.220206.013
ID  - Aquinas2022
ER  -