Histopathologic Evaluation of The Phyllodes Tumor

DOI

10.2991/phico-16.2017.6How to use a DOI?

Keywords

Phyllodes Tumor, Clinical Features, Histopathologic Features, Grade, Stromal Variations.

Abstract

Phyllodes tumor is a group of tumors with spesific histopathologic features. The characteristic feature is a double layered epithelial component arranged in clefts surrounded by an overgrowing hypercellular mesenchymal components typically organized in leaf-like structures. Adjunctions subclassifications as benign, borderline or malignant must be used when diagnosing a phyllodes tumor. The subclassifications differences were based on its histological characteristics and had been used to predict the biologic behaviour of the tumor. There are difficulties in diagnosing phyllodes tumor due to morphological resemblance with fibroadenomas and problems related to various stromal and glandular epithelium variations. Method. This is a descriptive study. Twenty-five slides and paraffin block from phyllodes tumor patients available at Departement of Anatomical Pathology Medical Faculty University of Sumatera Utara and Haji Adam Malik Hospital Medan were included in this study. The patients characteristics and histopathological features were evaluated using the hematoxilin-eosin slides. Results. A total of 25 women were diagnosed with phyllodes tumor during the study period. Their ages ranged from 20 to 59 years and 60% of them are over than 40 years. Histologic classification revealed 92% benign, 8% borderline and no malignant tumors. Majority benign and all borderline phyllodes tumors exhibit an enhanced intracanalicular growth pattern with leaf-like projections into dilated lumens. Majority of the tumors also exhibit myxoid degeneration. Conclusions. Histologic classification revealed benign tumors found in majority patients. Several histologic features such as an enhanced intracanalicular growth pattern and myxoid degeneration found in majority case.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Lokot Donna Lubis
PY  - 2016/12
DA  - 2016/12
TI  - Histopathologic Evaluation of The Phyllodes Tumor
BT  - Proceedings of the 1st Public Health International Conference (PHICo 2016)
PB  - Atlantis Press
SP  - 28
EP  - 33
SN  - 2468-5739
UR  - https://doi.org/10.2991/phico-16.2017.6
DO  - 10.2991/phico-16.2017.6
ID  - DonnaLubis2016/12
ER  -