Proceedings of the Soedirman International Conference on Mathematics and Applied Sciences (SICOMAS 2021)

Development of Ketorolac Analysis in Water Samples using Micellar Electrokinetic Chromatography

Authors
Dadan Hermawan1, *, Cacu Cacu1, Amin Fatoni1, Suwandri1, Wan Aini Wan Ibrahim2, Hassan Y Aboul-Enein3
1Department of Chemistry, Faculty of Mathematics and Natural Science, Jenderal Soedirman University, Indonesia
2Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 Johor Bahru, Malaysia
3Department of Pharmaceutical and Medical Chemistry, Pharmaceutical and Drug Industries Research Division, National Research Centre (NRC), Dokki, Cairo, Egypt
*Corresponding author. Email: dadan.hermawan@unsoed.ac.id
Corresponding Author
Dadan Hermawan
Available Online 25 May 2022.
DOI
https://doi.org/10.2991/apr.k.220503.003How to use a DOI?
Keywords
Ketorolac; Micellar electrokinetic chromatography; Water sample
Abstract

Quantitative determination of ketorolac, a nonsteroidal anti-inflammatory drug (NSAID) in water samples was reported using the micellar electrokinetic chromatography (MEKC) method. The on-line preconcentration technique at MEKC was then investigated to increase the detection sensitivity of ketorolac. A 6-fold increase in sensitivity factor was achieved using normal stacking mode (NSM)-MEKC. The average recovery of ketorolac in tap water samples was 102.16% (RSD = 0.06%). The current NSM-MEKC method is simple, has short analysis time, high accuracy, and uses fewer organic solvents (environmentally friendly).

Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license.

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Volume Title
Proceedings of the Soedirman International Conference on Mathematics and Applied Sciences (SICOMAS 2021)
Series
Advances in Physics Research
Publication Date
25 May 2022
ISBN
978-94-6239-579-4
ISSN
2352-541X
DOI
https://doi.org/10.2991/apr.k.220503.003How to use a DOI?
Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license.

Cite this article

TY  - CONF
AU  - Dadan Hermawan
AU  - Cacu Cacu
AU  - Amin Fatoni
AU  - Suwandri
AU  - Wan Aini Wan Ibrahim
AU  - Hassan Y Aboul-Enein
PY  - 2022
DA  - 2022/05/25
TI  - Development of Ketorolac Analysis in Water Samples using Micellar Electrokinetic Chromatography
BT  - Proceedings of the Soedirman International Conference on Mathematics and Applied Sciences (SICOMAS 2021)
PB  - Atlantis Press
SP  - 12
EP  - 16
SN  - 2352-541X
UR  - https://doi.org/10.2991/apr.k.220503.003
DO  - https://doi.org/10.2991/apr.k.220503.003
ID  - Hermawan2022
ER  -