Genetic Mutations in Causing Non-small Cell Lung Cancers and Related Drugs’ Efficiency

DOI

10.2991/assehr.k.220401.216How to use a DOI?

Keywords

Genes; mutations; therapy; drug; efficiency

Abstract

Gene mutations play an important role in the occurrence and development of tumors. The research on tumors at the gene level is more and more in-depth, especially in the mechanism of tumorigenesis and antitumor therapy. Common oncogenes are essential for the survival of all cells (not only tumor cells). Therefore, drugs targeting these genes are important for helping patients overcome cancers and extending life expectancy. The mutation research of the whole gene family has become a powerful tool in tumor genomics, which has brought a lot of progress. Gene families can be determined by similar sequences and protein domains. Since genes of the same gene family usually have similar functions, we can find the signal pathways related to tumorigenesis by systematically sequencing these genes in the tumor genome. Currently, more and more research focuses on creating drugs targeting specific genes and some drugs performed well in helping patients overcome cancers, especially non-small cell lung cancer. As one of the most adverse cancers, non-small lung cancer accounts for about 80 percentage of all lung cancer and nearly 75 percentage of patients were diagnosed lately with low 5-year survival rate. The research focused on understanding drugs targeted genes associated with non-small cell lung cancer would help us to treat patients efficiently. Up to now, a lot of genes were confirmed in involving in regulating the tumorigenesis, especially the KRAS, EGFR, AlK, MET, etc.

Copyright

© 2022 The Authors. Published by Atlantis Press SARL.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license.

Download article (PDF)

TY  - CONF
AU  - Zhiyou Ye
PY  - 2022
DA  - 2022/04/08
TI  - Genetic Mutations in Causing Non-small Cell Lung Cancers and Related Drugs’ Efficiency
BT  - Proceedings of the 2022 International Conference on Social Sciences and Humanities and Arts (SSHA 2022)
PB  - Atlantis Press
SP  - 1141
EP  - 1145
SN  - 2352-5398
UR  - https://doi.org/10.2991/assehr.k.220401.216
DO  - 10.2991/assehr.k.220401.216
ID  - Ye2022
ER  -