Progress in Mechanism of E.coli K1 Crossing the Blood-brain Barrier

DOI

10.2991/ssphe-18.2019.48How to use a DOI?

Keywords

E. coli K1, blood-brain barrier, Meningitis

Abstract

Meningitis is a serious central nervous system disease, E. coli K1 is the main pathogen that causes it. E.coli K1 triggers meningitis only if it crosses the blood-brain barrier(BBB), but the detail mechanism of how E. coli K1 cross the blood-brain barrier is still unclear. This article is based on current research, according to the sequence of E. coli K1 crossing the blood-brain barrier, introduce the mechanism from three sections: severe bacteremia, adhesion and invasion to brain microvascular endothelial cells (BMEC), rearrangement of cytoskeleton.

Copyright

© 2019, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Xiao Yang
AU  - Huiwen Tian
AU  - Shaoyi Lin
AU  - Jie Li
AU  - Shenghe Huang
AU  - Hong Cao
PY  - 2019/01
DA  - 2019/01
TI  - Progress in Mechanism of E.coli K1 Crossing the Blood-brain Barrier
BT  - Proceedings of the 2nd International Conference on Social Science, Public Health and Education (SSPHE 2018)
PB  - Atlantis Press
SP  - 201
EP  - 205
SN  - 2352-5398
UR  - https://doi.org/10.2991/ssphe-18.2019.48
DO  - 10.2991/ssphe-18.2019.48
ID  - Yang2019/01
ER  -