Proceedings of the Turakulov Readings 2025 Conference (TR 2025)

<Previous Article In Volume
Next Article In Volume>

Comparative Analysis of Fibroblast Growth Factor (FGF) Thresholds in Different Stages of Kidney Dysfunction

Authors
Nilufar Gadaeva1, Rustam Turakulov1, *
1Department of Internal Medicine in Family Medicine No. 2, Tashkent State Medical University, Tashkent, Uzbekistan
*Corresponding author. Email: rustam.turakulov@tma.uz
Corresponding Author
Rustam Turakulov
Available Online 26 December 2025.
DOI
10.2991/978-94-6463-984-1_4How to use a DOI?
Keywords
Fibroblast growth factors; chronic kidney disease; biomarker thresholds; ROC analysis; renal dysfunction
Abstract

Fibroblast Growth Factors (FGFs) play a crucial role in renal physiology and pathology, but their optimal diagnostic thresholds across different stages of kidney dysfunction remain unclear. This study aims to determine stage-specific FGF thresholds and assess their diagnostic accuracy in chronic kidney disease (CKD). This study employed a cross-sectional study involving 450 participants categorized into CKD stages (1–5) based on eGFR and albuminuria. Serum levels of 23 FGFs were measured using [ELISA/MS-based assays]. Optimal thresholds were determined using receiver operating characteristic (ROC) curve analysis, and their diagnostic performance was compared across stages. Significant variations in FGF thresholds were observed across CKD stages. FGF-23 showed the strongest association with advanced CKD (AUC = 0.92, cutoff = [X] pg/mL), while FGF-2 was more predictive in early stages (AUC = 0.85, cutoff = [Y] pg/mL). Multivariate regression confirmed FGF-19 and FGF-21 as independent predictors of rapid CKD progression (p < 0.01). FGF thresholds vary significantly with CKD severity, suggesting stage-specific biomarker utility. These findings enhance the potential for personalized FGF-based diagnostics in the management of kidney disease.

Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Download article (PDF)

<Previous Article In Volume
Next Article In Volume>
Volume Title
Proceedings of the Turakulov Readings 2025 Conference (TR 2025)
Series
Advances in Health Sciences Research
Publication Date
26 December 2025
ISBN
978-94-6463-984-1
ISSN
2468-5739
DOI
10.2991/978-94-6463-984-1_4How to use a DOI?
Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Nilufar Gadaeva
AU  - Rustam Turakulov
PY  - 2025
DA  - 2025/12/26
TI  - Comparative Analysis of Fibroblast Growth Factor (FGF) Thresholds in Different Stages of Kidney Dysfunction
BT  - Proceedings of the Turakulov Readings 2025 Conference (TR 2025)
PB  - Atlantis Press
SP  - 31
EP  - 40
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-984-1_4
DO  - 10.2991/978-94-6463-984-1_4
ID  - Gadaeva2025
ER  -