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Sorafenib (1) in the medical field to show the potential biological activity. Literature on the majority of tumor cells have a high biological activity, such as lymphoma, breast cancer, prostate cancer. However, some synthetic route of Sorafeni has disadvantages, such as low product yield and complicated...

4-(Thieno[3,2-d]pyrimidin-4-yl)morpholine derivatives is an important intermediate which inhibited tumor necrosis factor alpha and nitric oxide. In this work, a rapid and green synthetic method for compound (5) was established. The compound (5) was synthesized from the commercially available methyl 3-aminothiophene-2-carboxylate...

Afatinib (1) exhibited potential biological activities in medicine. There are shortcomings in the synthesis route of afatinib in the literature, the product yield is low and the post-processing is complicated. Therefore, in this paper, the two-step synthetic route of afatinib was optimized. The two-step...

To improve the teaching quality of "aquatic microbiology" course.The teaching reform exploration of aquatic microbiology was carried out in recent 5 years and summarized, which including grasping the course nature of "aquatic microbiology" by means of aquaculture professional training program, revising...

We propose a new feature selection procedure based on a combination of a pruning algorithm, Apriori mining techniques and fuzzy C-mean clustering. The feature selection algorithm is designed to mine on a multiresolution filter bank composed of rotationally invariant moments. The numerical experiments,...