Synthesis of 4-Chloro-N, N-Dimethyl Pyridine Car Box Amide
Yongli Duan, Zhimin Li, Qidong Tang, Rui Li, Shan Xu
Available Online February 2017.
- https://doi.org/10.2991/emcm-16.2017.111How to use a DOI?
- 4-chloro-N; N-dimethyl pyridine car box amide; Synthesis; Process optimization
- Sorafenib (1) in the medical field to show the potential biological activity. Literature on the majority of tumor cells have a high biological activity, such as lymphoma, breast cancer, prostate cancer. However, some synthetic route of Sorafeni has disadvantages, such as low product yield and complicated post-treatment. Therefore, in this paper, the main purpose is to optimize the Sorafeni part of the synthesis route. The effects of reaction reagent, feed and temperature on the yield of the reaction were discussed. The optimized reaction conditions were as follows SOCl2 : POCl3=5:1 and use K2CO3 instead of triethylamine.The structures were confirmed by 1H NMR.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Yongli Duan AU - Zhimin Li AU - Qidong Tang AU - Rui Li AU - Shan Xu PY - 2017/02 DA - 2017/02 TI - Synthesis of 4-Chloro-N, N-Dimethyl Pyridine Car Box Amide BT - 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016) PB - Atlantis Press SN - 2352-538X UR - https://doi.org/10.2991/emcm-16.2017.111 DO - https://doi.org/10.2991/emcm-16.2017.111 ID - Duan2017/02 ER -