Proceedings of the 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)

Synthesis of 4-Chloro-N, N-Dimethyl Pyridine Car Box Amide

Authors
Yongli Duan, Zhimin Li, Qidong Tang, Rui Li, Shan Xu
Corresponding Author
Yongli Duan
Available Online February 2017.
DOI
https://doi.org/10.2991/emcm-16.2017.111How to use a DOI?
Keywords
4-chloro-N; N-dimethyl pyridine car box amide; Synthesis; Process optimization
Abstract
Sorafenib (1) in the medical field to show the potential biological activity. Literature on the majority of tumor cells have a high biological activity, such as lymphoma, breast cancer, prostate cancer. However, some synthetic route of Sorafeni has disadvantages, such as low product yield and complicated post-treatment. Therefore, in this paper, the main purpose is to optimize the Sorafeni part of the synthesis route. The effects of reaction reagent, feed and temperature on the yield of the reaction were discussed. The optimized reaction conditions were as follows SOCl2 : POCl3=5:1 and use K2CO3 instead of triethylamine.The structures were confirmed by 1H NMR.
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This is an open access article distributed under the CC BY-NC license.

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Proceedings
2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)
Part of series
Advances in Computer Science Research
Publication Date
February 2017
ISBN
978-94-6252-297-8
ISSN
2352-538X
DOI
https://doi.org/10.2991/emcm-16.2017.111How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Yongli Duan
AU  - Zhimin Li
AU  - Qidong Tang
AU  - Rui Li
AU  - Shan Xu
PY  - 2017/02
DA  - 2017/02
TI  - Synthesis of 4-Chloro-N, N-Dimethyl Pyridine Car Box Amide
BT  - 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)
PB  - Atlantis Press
SN  - 2352-538X
UR  - https://doi.org/10.2991/emcm-16.2017.111
DO  - https://doi.org/10.2991/emcm-16.2017.111
ID  - Duan2017/02
ER  -