Synthesis of N-methylthieno [2, 3-d] Pyrimidin-4-amine Thienopyrimidine
Huajun Lei, Min Wang, Jiaqian Han, Zhou Lan
Available Online February 2017.
- https://doi.org/10.2991/emcm-16.2017.112How to use a DOI?
- Thieno [2,3-d] pyrimidine; Phosphoinositide 3-kinase; Synthesis
- Thieno[2,3-d]pyrimidine is a key intermediate in many biologically active compounds such as GDC-0941 and BKM 120. In this work, a rapid synthetic method for compound (4) was established. The compound (4) was synthesized from the commercially available methyl 2-aminothiophene-3-carboxylate and formimidamide through three steps including condensation reaction, chlorination, and nucleophilic substitution. The structure was confirmed by MS and 1H NMR. Furthermore, the total yield of the three steps was 54%.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Huajun Lei AU - Min Wang AU - Jiaqian Han AU - Zhou Lan PY - 2017/02 DA - 2017/02 TI - Synthesis of N-methylthieno [2, 3-d] Pyrimidin-4-amine Thienopyrimidine BT - 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016) PB - Atlantis Press SN - 2352-538X UR - https://doi.org/10.2991/emcm-16.2017.112 DO - https://doi.org/10.2991/emcm-16.2017.112 ID - Lei2017/02 ER -