Proceedings of the 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)

Synthesis of N-methylthieno [2, 3-d] Pyrimidin-4-amine Thienopyrimidine

Authors
Huajun Lei, Min Wang, Jiaqian Han, Zhou Lan
Corresponding Author
Huajun Lei
Available Online February 2017.
DOI
https://doi.org/10.2991/emcm-16.2017.112How to use a DOI?
Keywords
Thieno [2,3-d] pyrimidine; Phosphoinositide 3-kinase; Synthesis
Abstract
Thieno[2,3-d]pyrimidine is a key intermediate in many biologically active compounds such as GDC-0941 and BKM 120. In this work, a rapid synthetic method for compound (4) was established. The compound (4) was synthesized from the commercially available methyl 2-aminothiophene-3-carboxylate and formimidamide through three steps including condensation reaction, chlorination, and nucleophilic substitution. The structure was confirmed by MS and 1H NMR. Furthermore, the total yield of the three steps was 54%.
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Proceedings
2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)
Part of series
Advances in Computer Science Research
Publication Date
February 2017
ISBN
978-94-6252-297-8
ISSN
2352-538X
DOI
https://doi.org/10.2991/emcm-16.2017.112How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Huajun Lei
AU  - Min Wang
AU  - Jiaqian Han
AU  - Zhou Lan
PY  - 2017/02
DA  - 2017/02
TI  - Synthesis of N-methylthieno [2, 3-d] Pyrimidin-4-amine Thienopyrimidine
BT  - 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)
PB  - Atlantis Press
SN  - 2352-538X
UR  - https://doi.org/10.2991/emcm-16.2017.112
DO  - https://doi.org/10.2991/emcm-16.2017.112
ID  - Lei2017/02
ER  -