Artery Research

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Volume 4, Issue 4, December 2010, Pages 134 - 137

Adducin and its relation to cardiovascular system

Authors
Jitka Seidlerová*
Internal Department II, Faculty of Medicine in Pilsen, Charles University, Edvarda Beneše 13, Plzeň 323 95, Czech Republic
*Tel.: +420 377 40 22 50, +420 777 578 748 (mobile); fax: +420 377 40 23 74. E-mail address: seidlerovaji@fnplzen.cz.
Corresponding Author
Jitka Seidlerová
Available Online 12 December 2010.
DOI
10.1016/j.artres.2010.10.034How to use a DOI?
Keywords
Adducin; Arterial stiffness; Heart; Stroke
Abstract

Adducin is a cytoskleton protein, which functions within the cells as a heterodimer composed of a combination of three subunits, α, β and γ. Each of these subunits is coded by genes (ADD1, ADD2, ADD3) mapping to different chromosomes. Mutation in ADD1 Gly460Trp polymorphism is associated with increased Na+K+-ATPase activity and increased renal tubular sodium reabsorption, which leads to salt-sensitive hypertension. A number of studies focused on possible association between these genes alone, or together with the interaction with other modulatory genes or with the environment, in relation to cardiovascular phenotypes. Variations in adducin genes were shown to modulate intermediate phenotypes such as arterial distensibitity, carotid IMT and left ventricle diastolic function. Moreover, some studies demonstrated an association between adducin genes and coronary artery disease, stroke and mortality. We showed that genetic variations in ADD1, ADD3 and angiotensin II receptor type-1 receptor interactively influenced the elastic properties of brachial and femoral arteries. Concerning the antihypertensive treatment, it was speculated that carriers of mutated ADD1 460Trp allele might benefit from diuretic use, however the present findings on this subject remain inconsistent. In conclusion, adducin might play an important role in the cardiovascular system.

Copyright
© 2010 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
4 - 4
Pages
134 - 137
Publication Date
2010/12/12
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.10.034How to use a DOI?
Copyright
© 2010 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Jitka Seidlerová
PY  - 2010
DA  - 2010/12/12
TI  - Adducin and its relation to cardiovascular system
JO  - Artery Research
SP  - 134
EP  - 137
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.034
DO  - 10.1016/j.artres.2010.10.034
ID  - Seidlerová2010
ER  -