Artery Research

Volume 20, Issue C, December 2017, Pages 91 - 92

P109 PROGRESSION OF AORTIC ARCH CALCIFICATION AFTER KIDNEY TRANSPLANT AND ITS IMPORTANCE IN PREDICTING CARDIOVASCULAR RISK: SINGLE-CENTER 2-YEAR FOLLOW-UP STUDY

Authors
Agne Laucyte-Cibulskiene1, Evelina Boreikaite2, Gediminas Aucina2, Migle Gudynaite1, Ilona Rudminiene1, Sigita Anisko1, Loreta Vareikiene1, Liutauras Gumbys3, Nerijus Teresius3, Dileta Valanciene3, Ligita Ryliskyte4, Laurynas Rimsevicius1, Marius Miglinas1, Kestutis Strupas5
1Centre of Nephrology, Vilnius University Hospital Santaros Clinics, Vilnius, Lithuania
2Faculty of Medicine, Vilnius University, Lithuania
3Centre of Radiology and Nuclear Medicine, Vilnius University Hospital Santaros Clinics, Vilnius, Lithuania
4Department of Cardiovascular Medicine, Vilnius University Hospital Santaros Clinics, Vilnius, Lithuania
5Centre of Abdominal Surgery, Vilnius University Hospital Santaros Clinics, Vilnius, Lithuania
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.140How to use a DOI?
Abstract

Vascular calcification (VC) is linked to post-transplant cardiovascular events in the long term. We aimed to evaluate whether pretransplant chest X-ray based aortic arch calcification (AoAC) or pulse wave velocity measurement can better predict post- transplant cardiovascular or cerebrovascular events, and to assess the progression of calcification within 2 years.

Methods: Our single-center observational longitudinal study enrolled 40 kidney transplant recipients (KTR) without previous history of vascular events (no cardiovascular, cerebrovascular events, no peripheral artery disease). Two radiologists evaluated pretransplant and postransplant (after 2 years) AoAC on chest X-ray by using two different AoAC scales: AoAC grade evaluation [1] and AoAC score as suggested by Ogawa et al. in 2009 [2]. Cohen’s kappa coefficient was 0.75. The mismatching results were repeatedly reviewed and resulted in consensus. Carotid-femoral (cfPWV) and carotid-radial pulse wave velocity (crPWV) was measured using applanation tonometry and the PWV ratio (cfPWV/rPWV) was calculated. Patient clinical, biochemical data and cardiovascular/cerebrovascular event rate were monitored within 2 years.

Results: During 2-year follow-up 5 patients experienced cardiovascular events, which were predicted by PWV ratio, but not related to AoAC. In 3 patients, we observed progression of AoAC, in others – AoAC was less evident or remained unchanged in 2-years follow-up. AoAC score [2] could better describe the extent of vascular calcification in KTR.

Conclusions: KTR without previous vascular events have quite low cardiovascular/ cerebrovascular event rate within 2-year follow-up, which are better predicted by pretransplant PWV ratio. AoAC postransplant regression is evident even when using simplified chest X- ray scales.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
91 - 92
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.140How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Agne Laucyte-Cibulskiene
AU  - Evelina Boreikaite
AU  - Gediminas Aucina
AU  - Migle Gudynaite
AU  - Ilona Rudminiene
AU  - Sigita Anisko
AU  - Loreta Vareikiene
AU  - Liutauras Gumbys
AU  - Nerijus Teresius
AU  - Dileta Valanciene
AU  - Ligita Ryliskyte
AU  - Laurynas Rimsevicius
AU  - Marius Miglinas
AU  - Kestutis Strupas
PY  - 2017
DA  - 2017/12/06
TI  - P109 PROGRESSION OF AORTIC ARCH CALCIFICATION AFTER KIDNEY TRANSPLANT AND ITS IMPORTANCE IN PREDICTING CARDIOVASCULAR RISK: SINGLE-CENTER 2-YEAR FOLLOW-UP STUDY
JO  - Artery Research
SP  - 91
EP  - 92
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.140
DO  - 10.1016/j.artres.2017.10.140
ID  - Laucyte-Cibulskiene2017
ER  -