Artery Research

Volume 20, Issue C, December 2017, Pages 91 - 91

P108 IMPACT OF KIDNEY TRANSPLANTATION ON AORTIC STIFFNESS INDEX β0

Authors
Marie-Pier Desjardins1, Aboubacar Sidibé1, Catherine Fortier1, Fabrice Mac-Way1, Sacha De Serres1, Richard Larivière1, Bart Spronck2, Mohsen Agharazii1
1CHU de Québec Research Center, Hotel-Dieu de Québec hospital, Division of Nephrology, Université Laval, Québec City, Canada
2Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.139How to use a DOI?
Abstract

Purpose/ Background/ Objectives: We have shown that aortic stiffness improves as early as 3 months post-kidney transplantation (KTx). Aortic stiffness index β0, a blood pressure independent parameter, has been proposed to be a better indicator of vascular wall property. This study was designed to examine 1) the early versus late changes in aortic stiffness index β0 and 2) to define the characteristics of patients with favourable and unfavourable trajectories of aortic stiffness index β0 after KTx.

Methods: In 79 patients who underwent KTx, aortic stiffness was assessed before, 3, 6 and 24 months after KTx. Aortic stiffness was determined by carotid-femoral pulse wave velocity (cf-PWV), while aortic stiffness index β0 was obtained using a formulae proposed by Spronck and colleagues. Cytokines profile was measured in plasma by ELISA.

Results: There was a reduction of β0 3 months after KTx (29.0±2.0 to 25.8±1.2, P = 0.033). Then, aortic stiffness index β0 gradually increased at 6 (28.0±1.4, P = 0.005 vs 3 months) and 24 months (28.3±1.3, P = 0.003 vs 3 months). Unfavourable progression of β0 was not related to renal function, age, comorbidities or kidney donor characteristics. However, the unfavourable progression of β0 was associated with higher levels of interleukin-6 (P = 0.029).

Conclusions: The improvement of aortic stiffness index β0 3 months after KTx suggests that KTx leads to an early improvement of the intrinsic mechanical properties of aorta.

However, this improvement is followed by a late progression of β0, which is associated with increased pro-inflammatory cytokine, suggesting that activation of immune system may be involved in arterial wall remodeling in kidney transplant recipients.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
91 - 91
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.139How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Marie-Pier Desjardins
AU  - Aboubacar Sidibé
AU  - Catherine Fortier
AU  - Fabrice Mac-Way
AU  - Sacha De Serres
AU  - Richard Larivière
AU  - Bart Spronck
AU  - Mohsen Agharazii
PY  - 2017
DA  - 2017/12/06
TI  - P108 IMPACT OF KIDNEY TRANSPLANTATION ON AORTIC STIFFNESS INDEX β0
JO  - Artery Research
SP  - 91
EP  - 91
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.139
DO  - 10.1016/j.artres.2017.10.139
ID  - Desjardins2017
ER  -