6.10 PERIPHERAL SENSORY NEUROPATHY AND VASCULAR ANGIOGENIC FACTORS IN TYPE 2 DIABETES PATIENTS IN GHANA

DOI

10.1016/j.artres.2016.10.046How to use a DOI?

Abstract

Background: Impaired angiogenesis may be amongst the possible mechanism underlining the development of peripheral sensory neuropathy (PSN) in type 2 diabetes (T2DM) patients.(1) Angiogenesis is regulated by circulating vascular growth factor, notably, angiopoietin (Ang)-1, Ang-2 and vascular endothelial growth factor (VEGF).(2) We studied the relationship between PSN and circulating vascular growth factors, Ang-1, Ang-2 and VEGF in T2DM patients.

Method: PNS was assessed by vibration perception threshold (VPT) using Horwell’s neurothesiometer, and serum levels of Ang-1, Ang-2 and VEGF were also measured by Elisa in 107 T2DM patients and 93 nondiabetes subjects (controls). PNS was defined as VPT>25V.

Results: The overall prevalence of PNS was 11.2% higher in T2DM patients (10.1% vs. 1.1%, p=0.012) than controls. T2DM patients had higher mean VPT (12.1±7.8 vs. 7.3±3.8 V, p<0.001) than controls. Compared to those without PNS, PNS patients had lower Ang-2 levels [0.4 (0.2 – 0.8) vs. 0.8 (0.4 – 1.1) nmol/l, p=0.03] and higher VEGF levels [120 (60.8 – 254.4 vs. 59.4 (17.2 – 146.8), p=0.037], but no difference in Ang-1 levels. VPT was associated, positively with VEGF levels (r=0.22, p=0.003), and negatively with Ang-1 (r=−0.17, p=0.024), but not with Ang-2.

Discussion: Diabetes is associated with high prevalence of PNS and elevation of circulating vascular growth factors. PNS patients had imbalanced levels of circulating vascular growth factors, which may indicate impaired angiogenesis.

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TY  - JOUR
AU  - Kwame Yeboah
AU  - Daniel A. Antwi
AU  - Ben Gyan
PY  - 2016
DA  - 2016/11/24
TI  - 6.10 PERIPHERAL SENSORY NEUROPATHY AND VASCULAR ANGIOGENIC FACTORS IN TYPE 2 DIABETES PATIENTS IN GHANA
JO  - Artery Research
SP  - 61
EP  - 62
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.046
DO  - 10.1016/j.artres.2016.10.046
ID  - Yeboah2016
ER  -