11.10 ARTERIAL ELASTANCE IS ASSOCIATED WITH CENTRAL BLOOD PRESSURE AND ARTERIAL PERIPHERAL RESISTANCE IN PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION
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Objective of the study was to assess ventricular-arterial coupling (VAC), parameters of left ventricular (LV) work efficiency and their determinants in patients with arterial hypertension (HTN) and stable heart failure with reduced ejection fraction (HFrEF).
Methods: In 93 stable patients with HTN and HFrEF 2-dimentional echocardiography was used to assess arterial elastance (Ea) and end systolic LV elastance (Ees). VAC was assessed as the ratio Ea/Ees. Mann-Witney test and multivariate analysis was performed. P<0.05 was considered significant.
Results: The range of VAC was 0.9–4.7. VAC >1.2 (upper optimal level) was revealed in 87%. Ea positively correlated with aortic systolic BP, office diastolic BP, arterial peripheral resistance, systole duration, negatively – with body mass index (BMI). Ees positively correlated with EF, office systolic and diastolic BP, negatively – with LV mass index (LVMI). Increased VAC was associated with decrease of office and aortic systolic BP, BMI, LV EF, increase of LVMI and NT-proBNP.
Conclusions: Impairment of functioning of cardio-vascular system assessed by increased value of VAC> 1.2 was revealed in 87% of patients with HTN and stable HFrEF. Increase of VAC was associated predominantly with decrease of Ees and LV work efficiency (SW/PVA). In HFrEF LV and arterial system matched to maximize SW. VAC and its components are associated with echocardiographic parameters and markers of arterial stiffness.
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TY - JOUR AU - Evgeny Tyukhmenev AU - Svetlana Villevalde AU - Zhanna Kobalava PY - 2016 DA - 2016/11/24 TI - 11.10 ARTERIAL ELASTANCE IS ASSOCIATED WITH CENTRAL BLOOD PRESSURE AND ARTERIAL PERIPHERAL RESISTANCE IN PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION JO - Artery Research SP - 76 EP - 76 VL - 16 IS - C SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2016.10.098 DO - https://doi.org/10.1016/j.artres.2016.10.098 ID - Tyukhmenev2016 ER -