Artery Research

Volume 12, Issue C, December 2015, Pages 46 - 46

5.3 THE INFLUENCE OF SEX AND AGE ON ARTERIAL FUNCTION IN RESPONSE TO AN ACUTE INFLAMMATORY STIMULUS

Authors
Alexander Rosenberg*1, Abbi Lane-Cordova2, Kanokwan Bunsawat1, Sang Ouk Wee1, Tracy Baynard1, Bo Fernhall1
1University of Illinois at Chicago, Chicago, Il, USA
2University of Iowa, Iowa City, IA, USA
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.028How to use a DOI?
Abstract

Background: Aging is associated with increased arterial stiffness and chronic low-grade inflammation. Acute inflammatory stimulus in the presence of low-grade chronic inflammation briefly increases the risk of cardiovascular events. The risk of cardiovascular events also increases substantially in older compared to younger women, therefore the relationship between sex and aging is important to understand.

Purpose: To describe the differential effects of age following induced systemic inflammation on arterial function, endothelial function, and wave reflection.

Method: Healthy volunteers aged 18–35 yrs (n = 18, ≈26yr, male = 6) or 55–75 yrs (n = 21, ≈64yr, male = 9) participated. Ultrasound of the common carotid and brachial artery was performed, Beta-stiffness (β) and flow mediated dilation (FMD) were calculated. Aortic mean arterial (aMAP), pulse wave analysis with wave separation, pulse wave velocity (PWV) measurements were obtained in the supine position at rest using applanation tonometry. Participants received an influenza vaccine to induce acute inflammation following baseline measurements and returned for 24-hour follow-up.

Results: C-reactive protein and interlukin-6 increased pre-to-post similar in all groups (p < 0.05). β was higher for older adults pre/post. (p < 0.05). Older males exhibited decreased MAP and reflected wave pressure (RP), but increased PWV following vaccination (p < 0.05). However, FMD significantly decreased only in young males.

Conclusion: The results suggest that differential responses occur between young and older adults and between males and females in response to acute inflammation. Although inflammation increased similarly, inflammation had limited effects on vascular function in both young and old females, suggesting there are significant sex effects for arterial function in response to acute inflammation.

Open Access
This is an open access article distributed under the CC BY-NC license.

Download article (PDF)
View full text (HTML)

Journal
Artery Research
Volume-Issue
12 - C
Pages
46 - 46
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.028How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Alexander Rosenberg*
AU  - Abbi Lane-Cordova
AU  - Kanokwan Bunsawat
AU  - Sang Ouk Wee
AU  - Tracy Baynard
AU  - Bo Fernhall
PY  - 2015
DA  - 2015/11/23
TI  - 5.3 THE INFLUENCE OF SEX AND AGE ON ARTERIAL FUNCTION IN RESPONSE TO AN ACUTE INFLAMMATORY STIMULUS
JO  - Artery Research
SP  - 46
EP  - 46
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.028
DO  - 10.1016/j.artres.2015.10.028
ID  - Rosenberg*2015
ER  -