The Association between Retinal and Central Pulse Wave Velocity in the Elderly

Mahdieh Rezaeian; S. Mojtaba Golzan; Alberto P. Avolio; Stuart Graham; Mark Butlin

doi:10.2991/artres.k.200203.001

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Volume 26, Issue 3, September 2020, Pages 148 - 153

The Association between Retinal and Central Pulse Wave Velocity in the Elderly

Authors

Mahdieh Rezaeian¹, S. Mojtaba Golzan², Alberto P. Avolio³, Stuart Graham¹, Mark Butlin³^{, *}

¹Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia

²Vision Science Group, Graduate School of Health, University of Technology Sydney, Sydney, Australia

³Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia

^*Corresponding author. Email: mark.butlin@mq.edu.au

Corresponding Author

Mark Butlin

Received 20 December 2019, Accepted 31 January 2020, Available Online 11 February 2020.

DOI: 10.2991/artres.k.200203.001 How to use a DOI?
Keywords: Retinal artery; small vessel; arterial stiffness; pulse wave velocity
Abstract: Purpose: The retina provides a non-invasive window to monitor microvascular circulation. Carotid-femoral Pulse Wave Velocity (cfPWV) is an indicator of large artery stiffness and is associated with systemic cardiovascular diseases. This study investigates whether Retinal artery PWV (rPWV) reflects cfPWV changes in an elderly cohort.

Methods: A total of 37 elderly participants (28 female, age 79 ± 5 years) were studied. Participants with a history of diabetes, glaucoma, and any neurological or eye-related disorders were excluded. Twenty four subjects were taking antihypertensive medication. A 60-s recording of retinal arterial diameter changes were captured (25 Hz frame rate, Dynamic Vessel Analyzer). Systolic blood pressure, Diastolic Blood Pressure (DBP), cfPWV and Intraocular Pressure (IOP) were measured. A custom-written algorithm was used to extract pulse amplitudes from retinal arterial diameters within one- and three-disc diameters from the optic disc. rPWV was designated as the ratio of the distance between two sites along the artery to the time delay between pulses. Predictors of rPWV were assessed by linear regression and parameter selection techniques.

Results: There was a positive correlation between rPWV and cfPWV (Pearson’s correlation coefficient 0.82, p < 0.001). In parameter selection models, cfPWV, transmural pressure (DBP–IOP), male sex, and IOP were isolated as predictors of rPWV.

Conclusion: This study found a positive correlation between rPWV and cfPWV in an elderly cohort. This indicates that microvessel remodelling that parallels large vessel remodelling is able to be detected using rPWV measurement. Further longitudinal studies are required to elucidate the predictive value of screening rPWV in systemic cardiovascular abnormalities.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal: Artery Research
Volume-Issue: 26 - 3
Pages: 148 - 153
Publication Date: 2020/02/11
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.200203.001 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Mahdieh Rezaeian
AU  - S. Mojtaba Golzan
AU  - Alberto P. Avolio
AU  - Stuart Graham
AU  - Mark Butlin
PY  - 2020
DA  - 2020/02/11
TI  - The Association between Retinal and Central Pulse Wave Velocity in the Elderly
JO  - Artery Research
SP  - 148
EP  - 153
VL  - 26
IS  - 3
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.200203.001
DO  - 10.2991/artres.k.200203.001
ID  - Rezaeian2020
ER  -

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