Artery Research

Volume 2, Issue 2, May 2008, Pages 67 - 73

Canola oil decreases cholesterol and improves endothelial function in patients with peripheral arterial occlusive disease – a pilot study

Authors
Hans Stricker*, Francesca Duchini, Marco Facchini, Giorgio Mombelli
Ospedale La Carità, Department of Medicine, CH-6600 Locarno, Switzerland

Funding Sources: The study was partly funded by the Fondo Balli, Locarno, Switzerland.

*Corresponding author. Ospedale La Carità, Department of Medicine, Via all’Ospedale, CH-6600 Locarno, Switzerland. Tel.: +41 91 811 4549; fax: +41 91 811 4783. E-mail address: hans.stricker@eoc.ch (H. Stricker).
Corresponding Author
Hans Stricker
Received 7 November 2007, Revised 3 February 2008, Accepted 4 February 2008, Available Online 12 March 2008.
DOI
https://doi.org/10.1016/j.artres.2008.02.001How to use a DOI?
Keywords
Peripheral arterial occlusive disease, Atherosclerosis, Polyunsaturated fatty acids, Endothelial function, Canola oil
Abstract

Background: Dietary supplementation with omega-3 PUFAs has been shown to reduce cardiovascular morbidity and mortality. This pilot study investigated the effects of supplementation with plant-derived omega-3 and omega-6 PUFAs in patients with atherosclerosis.

Methods: Forty patients with PAD supplemented their usual diet with 2 tablespoons/day of canola oil (n = 20) or sunflower oil (n = 20), containing 2.24 g of α-linolenic acid or 16.24 g of linoleic acid, respectively, for 8 weeks. Laser Doppler flux (LDF), was assessed at rest and during reactive hyperaemia. Other measurements included parameters of heart rate variability (HRV), markers of plasmatic coagulation, fibrinolysis, platelet activation, inflammation, and lipid and homocysteine levels.

Results: Despite randomization, baseline values for LDF and HRV differed between the two groups. LDL-cholesterol decreased (from 2.74 ± 0.73 to 2.42 ± 0.65 mmol/L, p = 0.007) with canola oil but not with sunflower oil. The difference in the percent increase of LDF after ischemic challenge increased with canola oil from a median (25th; 75th percentiles) of 75.2% (48.6; 161.2) to 151.7% (117.8; 260.0) (p = 0.008) and with sunflower oil from 157.9% (125.4; 229.8) to 178.6% (127.3; 356.3) (p = 0.03), whereas a control group did show no change. HRV and other markers did not change.

Conclusions: Canola oil containing omega-3 PUFAs may confer cardiovascular protection by improving endothelial function and lowering LDL-cholesterol, but additional studies are warranted.

Copyright
© 2008 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
2 - 2
Pages
67 - 73
Publication Date
2008/03/12
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
https://doi.org/10.1016/j.artres.2008.02.001How to use a DOI?
Copyright
© 2008 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Hans Stricker
AU  - Francesca Duchini
AU  - Marco Facchini
AU  - Giorgio Mombelli
PY  - 2008
DA  - 2008/03/12
TI  - Canola oil decreases cholesterol and improves endothelial function in patients with peripheral arterial occlusive disease – a pilot study☆
JO  - Artery Research
SP  - 67
EP  - 73
VL  - 2
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2008.02.001
DO  - https://doi.org/10.1016/j.artres.2008.02.001
ID  - Stricker2008
ER  -