Canola oil decreases cholesterol and improves endothelial function in patients with peripheral arterial occlusive disease – a pilot study☆
Funding Sources: The study was partly funded by the Fondo Balli, Locarno, Switzerland.
- 10.1016/j.artres.2008.02.001How to use a DOI?
- Peripheral arterial occlusive disease; Atherosclerosis; Polyunsaturated fatty acids; Endothelial function; Canola oil
Background: Dietary supplementation with omega-3 PUFAs has been shown to reduce cardiovascular morbidity and mortality. This pilot study investigated the effects of supplementation with plant-derived omega-3 and omega-6 PUFAs in patients with atherosclerosis.
Methods: Forty patients with PAD supplemented their usual diet with 2 tablespoons/day of canola oil (n = 20) or sunflower oil (n = 20), containing 2.24 g of α-linolenic acid or 16.24 g of linoleic acid, respectively, for 8 weeks. Laser Doppler flux (LDF), was assessed at rest and during reactive hyperaemia. Other measurements included parameters of heart rate variability (HRV), markers of plasmatic coagulation, fibrinolysis, platelet activation, inflammation, and lipid and homocysteine levels.
Results: Despite randomization, baseline values for LDF and HRV differed between the two groups. LDL-cholesterol decreased (from 2.74 ± 0.73 to 2.42 ± 0.65 mmol/L, p = 0.007) with canola oil but not with sunflower oil. The difference in the percent increase of LDF after ischemic challenge increased with canola oil from a median (25th; 75th percentiles) of 75.2% (48.6; 161.2) to 151.7% (117.8; 260.0) (p = 0.008) and with sunflower oil from 157.9% (125.4; 229.8) to 178.6% (127.3; 356.3) (p = 0.03), whereas a control group did show no change. HRV and other markers did not change.
Conclusions: Canola oil containing omega-3 PUFAs may confer cardiovascular protection by improving endothelial function and lowering LDL-cholesterol, but additional studies are warranted.
- © 2008 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
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Cite this article
TY - JOUR AU - Hans Stricker AU - Francesca Duchini AU - Marco Facchini AU - Giorgio Mombelli PY - 2008 DA - 2008/03/12 TI - Canola oil decreases cholesterol and improves endothelial function in patients with peripheral arterial occlusive disease – a pilot study☆ JO - Artery Research SP - 67 EP - 73 VL - 2 IS - 2 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2008.02.001 DO - 10.1016/j.artres.2008.02.001 ID - Stricker2008 ER -