Artery Research

Volume 26, Issue 3, September 2020, Pages 170 - 179

Study Protocol – Insight 46 Cardiovascular: A Sub-study of the MRC National Survey of Health and Development

Authors
Sarah Ann Mason1, *, Lamia Al Saikhan1, 4, Siana Jones1, Gemma Bale2, Sarah-Naomi James1, 3, Heidi Murray-Smith3, Alicja Rapala1, Suzanne Williams1, Brian Wong1, Marcus Richards1, Nick C. Fox3, Rebecca Hardy1, Jonathan M. Schott1, 3, Nish Chaturvedi1, Alun D. Hughes1
1MRC Unit for Lifelong Health and Ageing at UCL, Department of Population Science & Experimental Medicine, UCL Institute of Cardiovascular Science, University College London, London, UK
2Department of Medical Physics and Biomedical Engineering, University College London, London, UK
3Dementia Research Centre, Institute of Neurology, University College London, London, UK
4Department of Cardiac Technology, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, 2835 King Faisal Street, Dammam, Kingdom of Saudi Arabia
*Corresponding author. Email: s.mason@ucl.ac.uk
Corresponding Author
Sarah Ann Mason
Received 23 January 2020, Accepted 6 April 2020, Available Online 24 April 2020.
DOI
https://doi.org/10.2991/artres.k.200417.001How to use a DOI?
Keywords
Dementia; cognitive decline; vascular cognitive impairment; functional near infrared spectroscopy (fNIRS)
Abstract

The commonest causes of dementia are Alzheimer’s disease and vascular cognitive impairment. Although these conditions have been viewed as distinct entities, there is increasing evidence that neurodegenerative and vascular pathologies interact or overlap to cause cognitive decline, and that at least in some cases individuals at risk of cognitive decline exhibit abnormal cardiovascular physiology long before emergence of disease. However, the mechanisms linking haemodynamic disturbances with cognitive impairment and the various pathologies that cause dementia are poorly understood. A sub-sample of 502 participants from the Medical Research Council National Survey of Health and Development (NSHD) have participated in the first visit of a neuroscience sub-study referred to as Insight 46, where clinical, cognitive, imaging, and lifestyle data have been collected for the purpose of elucidating the pathological changes preceding dementia. This paper outlines the cardiovascular phenotyping performed in the follow-up visit of Insight 46, with the study participants now aged 74. In addition to standard cardiovascular assessments such as blood pressure measurements, echocardiography, and electrocardiography (ECG), functional Near Infrared Spectroscopy (fNIRS) has been included to provide an assessment of cerebrovascular function. A detailed description of the fNIRS protocol along with preliminary results from pilot data is presented. The combination of lifestyle data, brain structure/function, cognitive performance, and cardiovascular health obtained not only from Insight 46, but also from the whole NSHD provides an exciting opportunity to advance our understanding of the cardiovascular mechanisms underlying dementia and cognitive decline, and identify novel targets for intervention.

Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Artery Research
Volume-Issue
26 - 3
Pages
170 - 179
Publication Date
2020/04/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
https://doi.org/10.2991/artres.k.200417.001How to use a DOI?
Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Sarah Ann Mason
AU  - Lamia Al Saikhan
AU  - Siana Jones
AU  - Gemma Bale
AU  - Sarah-Naomi James
AU  - Heidi Murray-Smith
AU  - Alicja Rapala
AU  - Suzanne Williams
AU  - Brian Wong
AU  - Marcus Richards
AU  - Nick C. Fox
AU  - Rebecca Hardy
AU  - Jonathan M. Schott
AU  - Nish Chaturvedi
AU  - Alun D. Hughes
PY  - 2020
DA  - 2020/04/24
TI  - Study Protocol – Insight 46 Cardiovascular: A Sub-study of the MRC National Survey of Health and Development
JO  - Artery Research
SP  - 170
EP  - 179
VL  - 26
IS  - 3
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.200417.001
DO  - https://doi.org/10.2991/artres.k.200417.001
ID  - Mason2020
ER  -