Role of Adipose Tissue and Skeletal Muscle in Atherosclerosis and in Central Hemodynamics
- 10.2991/artres.k.200511.001How to use a DOI?
- Carotid arterial disease; peripheral arterial disease; atherosclerosis; arteriosclerosis; adipose tissue; skeletal muscle
Background: Carotid Arterial Disease (CAD) and peripheral arterial disease (PAD) are atherosclerotic diseases. Adipose tissue (AT) and skeletal muscle (SM) are endocrine organs producing polypeptides with vascular effects. The main objective of this study is to characterize the AT and SM in PAD and CAD. It is also an aim to determine their role in central hemodynamics.
Methods: A prospective, observational, case–control study is being conducted. The study group includes patients with PAD/CAD, with and without surgical indication. The control group includes subjects without PAD/CAD, with indication for elective non-vascular surgery, in order to allow access to samples of AT and SM. The quantity, histology and endocrine function of AT and SM are being determined.
Results: From December 2018 to August 2019, 47 PAD were studied: 33 with Intermittent Claudication (IC) - (28 male; age: 67.24 ± 9.97 years) and 14 Critical Limb Ischemia (CLI) - (seven male; age: 69.21 ± 8.33 years). CLI patients have a lower quantity of SM and higher quantity of visceral and subcutaneous AT, determined on the CT scan, but these differences were not statistically significant. CLI had significant lower SM strength and density [muscle strength right hand: 22.62 ± 8.20 kgf IC vs. 16.38 ± 7.84 kgf CLI, p = 0,02; SM strength left hand: 21.98 ± 8.98 kgf IC vs. 16.37 ± 8.35 kgf CLI, p = 0.04; SM density: 20.44 ± 11.73 Hounsfield Units (HU) IC vs. 9.04 ± 2.47 HU CLI, p = 0.01].
Conclusion: This preliminary data suggests that CLI patients could have a SM dysfunction, inferred from hand grip strength and SM density. These results would be corroborated with the project development. The novelty of this research is the possibility to study the histology features and endocrine markers of AT and SM and to find an association with artery function, arteriosclerosis an atherosclerosis, in human.
- © 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - JOUR AU - Joana Ferreira AU - Pedro Cunha AU - Armando Mansilha AU - Cristina Cunha AU - Cristina Silva AU - Isabel Vila AU - Alexandre Carneiro AU - Amílcar Mesquita AU - Jorge Cotter PY - 2020 DA - 2020/05/15 TI - Role of Adipose Tissue and Skeletal Muscle in Atherosclerosis and in Central Hemodynamics JO - Artery Research SP - 76 EP - 83 VL - 26 IS - 2 SN - 1876-4401 UR - https://doi.org/10.2991/artres.k.200511.001 DO - 10.2991/artres.k.200511.001 ID - Ferreira2020 ER -