Role of Adipose Tissue and Skeletal Muscle in Atherosclerosis and in Central Hemodynamics

Joana Ferreira; Pedro Cunha; Armando Mansilha; Cristina Cunha; Cristina Silva; Isabel Vila; Alexandre Carneiro; Amílcar Mesquita; Jorge Cotter

doi:10.2991/artres.k.200511.001

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Volume 26, Issue 2, June 2020, Pages 76 - 83

Role of Adipose Tissue and Skeletal Muscle in Atherosclerosis and in Central Hemodynamics

Authors

Joana Ferreira¹^{, 2}^{, 3}^{, *}, Pedro Cunha²^{, 3}^{, 4}, Armando Mansilha⁵^{, 6}, Cristina Cunha⁴, Cristina Silva⁴, Isabel Vila⁴, Alexandre Carneiro⁷, Amílcar Mesquita¹, Jorge Cotter²^{, 3}^{, 4}

¹Vascular Surgery Department, Hospital da Senhora da Oliveira, Guimarães, Portugal Rua dos Cutileiros Creixomil, Guimarães 4835-044, Portugal

²Life and Health Science Research Institute (ICVS), School of Medicine, University of Minho, Portugal Campus de Gualtar, Braga 4710-057, Portugal

³Centro Académico Department, Hospital da Senhora da Oliveira, Guimarães, Portugal

⁴Center for the Research and Treatment of Arterial Hypertension and Cardiovascular Risk, Internal Medicine Department, Hospital da Senhora da Oliveira, Guimarães, Portugal

⁵Faculdade de Medicina da Universidade do Porto, Al. Prof. Hernâni Monteiro, Porto 4200-319, Portugal

⁶Vascular Surgery Department, Hospital de São João, Porto, Portugal

⁷Radiology Department, Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real 5000-508, Portugal

^*Corresponding author. Email: joana222@gmail.com

Corresponding Author

Joana Ferreira

Received 30 November 2019, Accepted 2 May 2020, Available Online 15 May 2020.

DOI: 10.2991/artres.k.200511.001 How to use a DOI?
Keywords: Carotid arterial disease; peripheral arterial disease; atherosclerosis; arteriosclerosis; adipose tissue; skeletal muscle
Abstract: Background: Carotid Arterial Disease (CAD) and peripheral arterial disease (PAD) are atherosclerotic diseases. Adipose tissue (AT) and skeletal muscle (SM) are endocrine organs producing polypeptides with vascular effects. The main objective of this study is to characterize the AT and SM in PAD and CAD. It is also an aim to determine their role in central hemodynamics.

Methods: A prospective, observational, case–control study is being conducted. The study group includes patients with PAD/CAD, with and without surgical indication. The control group includes subjects without PAD/CAD, with indication for elective non-vascular surgery, in order to allow access to samples of AT and SM. The quantity, histology and endocrine function of AT and SM are being determined.

Results: From December 2018 to August 2019, 47 PAD were studied: 33 with Intermittent Claudication (IC) - (28 male; age: 67.24 ± 9.97 years) and 14 Critical Limb Ischemia (CLI) - (seven male; age: 69.21 ± 8.33 years). CLI patients have a lower quantity of SM and higher quantity of visceral and subcutaneous AT, determined on the CT scan, but these differences were not statistically significant. CLI had significant lower SM strength and density [muscle strength right hand: 22.62 ± 8.20 kgf IC vs. 16.38 ± 7.84 kgf CLI, p = 0,02; SM strength left hand: 21.98 ± 8.98 kgf IC vs. 16.37 ± 8.35 kgf CLI, p = 0.04; SM density: 20.44 ± 11.73 Hounsfield Units (HU) IC vs. 9.04 ± 2.47 HU CLI, p = 0.01].

Conclusion: This preliminary data suggests that CLI patients could have a SM dysfunction, inferred from hand grip strength and SM density. These results would be corroborated with the project development. The novelty of this research is the possibility to study the histology features and endocrine markers of AT and SM and to find an association with artery function, arteriosclerosis an atherosclerosis, in human.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal: Artery Research
Volume-Issue: 26 - 2
Pages: 76 - 83
Publication Date: 2020/05/15
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.200511.001 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Joana Ferreira
AU  - Pedro Cunha
AU  - Armando Mansilha
AU  - Cristina Cunha
AU  - Cristina Silva
AU  - Isabel Vila
AU  - Alexandre Carneiro
AU  - Amílcar Mesquita
AU  - Jorge Cotter
PY  - 2020
DA  - 2020/05/15
TI  - Role of Adipose Tissue and Skeletal Muscle in Atherosclerosis and in Central Hemodynamics
JO  - Artery Research
SP  - 76
EP  - 83
VL  - 26
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.200511.001
DO  - 10.2991/artres.k.200511.001
ID  - Ferreira2020
ER  -

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