The Human Systemic and Cerebral Circulations: Contrasts in Structure and Function
- https://doi.org/10.2991/artres.k.200704.001How to use a DOI?
- Wave reflection, reflection coefficient, pressure waves, flow waves, intracranial pressure, pulse wave analysis
Apart from peculiarities of the cerebral circulation, required to perfuse the brain with the subject erect, the principles established for function of the human systemic circulation (pulsatile flow at input and steady flow at output in capillaries) are identical to those established for other mammals. Assumption of the erect posture first as Homo erectus, then as Homo sapiens, conferred huge advantage to humans and led to command of the mammalian kingdom. But this required a circulation which could perfuse the brain securely against gravity in all positions of the body. This review covers what presently is known about the human cerebral circulation, and how such knowledge can be applied in some clinical conditions including development of dementia in older subjects, and in management of patients with elevation of intra-cranial pressure in younger subjects.
- © 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - JOUR AU - Michael O’Rourke AU - Jonathan Stone AU - Audrey Adji AU - Mi Ok Kim AU - Yan Li AU - Ji Guang Wang AU - Alberto Avolio AU - Per Kristian Eide AU - Marek Czosnyka PY - 2020 DA - 2020/07 TI - The Human Systemic and Cerebral Circulations: Contrasts in Structure and Function JO - Artery Research SN - 1876-4401 UR - https://doi.org/10.2991/artres.k.200704.001 DO - https://doi.org/10.2991/artres.k.200704.001 ID - O’Rourke2020 ER -