Artery Research

Volume 27, Issue 3, September 2021, Pages 121 - 128

Pre-existing Cerebral Small Vessel Disease in Young Patients with Acute Ischemic Stroke caused by Large Artery Atherosclerosis or Small Artery Occlusion

Authors
Hui Li1, #, Dan Du1, #, Juan Chen2, Xiang Wang1, *, Yuanliang Xie1, *
1Department of Radiology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, No. 26 Shengli Street, Jiangan District, Wuhan City, Hubei Province 430014, China
2Department of Neurology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, No. 26 Shengli Street, Jiangan District, Wuhan City, Hubei Province 430014, China
#

Hui Li and Dan Du are both the co-first author of this study.

*Corresponding authors. Email: xiangwang19125@126.com; drxieyuanliang@163.com
Corresponding Author
Xiang Wang
Received 22 March 2021, Accepted 8 April 2021, Available Online 16 May 2021.
DOI
https://doi.org/10.2991/artres.k.210511.001How to use a DOI?
Keywords
Young, pre-existing cerebral small vessel disease, acute ischemic stroke, large artery atherosclerosis, small artery occlusion
Abstract

Objective: To explore the characteristics of pre-existing Cerebral Small Vessel Disease (CSVD) in young patients with Acute Ischemic Stroke (AIS) caused by large artery atherosclerosis or small artery occlusion.

Methods: A total of 400 patients with suspected stroke or transient ischemic attack who aged 18–45 years old were included in this retrospective study. Demography data, vascular risk factors and primary CSVD were compared between patients with AIS and non-stroke or between patients with different subtypes of AIS.

Results: The levels of cerebrovascular risk factors were significantly higher in patients with AIS than those with non-stroke (p < 0.05). The majority of patients with large artery atherosclerotic stroke or small artery occlusive stroke were male. The age was slightly younger and the NIH stroke scale (NIHSS) score at admission were higher in large artery atherosclerotic stroke group than small artery occlusive stroke group. White matter hyperintensities, moderate and extensive enlarged perivascular space, 1–3 points of total score were more commonly observed in patients with AIS than those with non-stroke (p < 0.05). Male and diabetes were the risk factors of lacune infarctions (p < 0.05). Male, hypertension and primary CSVD were the risk factors of both of strokes (p < 0.05). The enlarged perivascular space notably increased the risk of large artery atherosclerotic stroke (p = 0.033).

Conclusion: Male, age, hypertension, diabetes and pre-existing CSVD were the risk factors of young patients with AIS. For young adults, once asymptomatic CSVD abnormalities were detected, cerebrovascular risk factors should be screened and pre-existing prevention measures for stroke should be taken.

Copyright
© 2021 The Authors. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Artery Research
Volume-Issue
27 - 3
Pages
121 - 128
Publication Date
2021/05/16
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
https://doi.org/10.2991/artres.k.210511.001How to use a DOI?
Copyright
© 2021 The Authors. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Hui Li
AU  - Dan Du
AU  - Juan Chen
AU  - Xiang Wang
AU  - Yuanliang Xie
PY  - 2021
DA  - 2021/05/16
TI  - Pre-existing Cerebral Small Vessel Disease in Young Patients with Acute Ischemic Stroke caused by Large Artery Atherosclerosis or Small Artery Occlusion
JO  - Artery Research
SP  - 121
EP  - 128
VL  - 27
IS  - 3
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.210511.001
DO  - https://doi.org/10.2991/artres.k.210511.001
ID  - Li2021
ER  -