Intensive Care Research

Latest Articles

Research Article

Clinical Features and Prognosis of B-cell Lymphoma-associated Hemophagocytic Syndrome: A Retrospective Single Center Study

Huting Hou, Xudong Zhang, Siyu Qian, Zeyuan Wang, Meng Dong, Xiaojuan Zhang, Xiaoguang Duan, Yue Zhang, Qing Wen, Jingjing Ge, Yaxin Lei, Mingzhi Zhang, Qingjiang Chen
Volume 1, Issue 3-4, December 2021, Pages 45-50
Purpose: Current knowledge of Lymphoma Associated Hemophagocytic Syndrome (LAHS) mainly relies on T/NK-cell LAHS cases, while B-cell lymphoma associated hemophagocytic syndrome (B-LAHS) variant are rare. We aimed at identifying a single-center cohort of patients with B-LAHS to shed light on relevant...
Research Article

Transesophageal Pacing Cardiac Induces Cardiac Arrest and Subsequent Brain Injury in Rats

Yingtao Lian, Lan Yao, Song Xu, Liping Lu, Teng Wang, Guo Hou, Yinping Li, Zhui Yu
Volume 1, Issue 3-4, December 2021, Pages 37-44
Background: Cardiac Arrest (CA) is one of the leading causes of mortality worldwide. The present study aimed to establish a simple and stable rat model of CA induced by transesophageal cardiac pacing for the investigation of cerebral resuscitation. Materials and Methods: A total of 26 healthy adult...

Intubated, Awake, and Paralysed: A Never Event

Huw Mayberry, Alyssa M. Burgart, Constantinos Kanaris
Volume 1, Issue 3-4, December 2021, Pages 60-64
In this paper, we argue that paralysis-only intubation is almost never acceptable practice. We look at the evidence suggesting that this practice remains commonplace worldwide, its frequency has been exacerbated further by anaesthetic drug shortages secondary to the COVID-19 pandemic. We make a strong...

Post-Intubation Empirical Fluid Resuscitation as an Early Step to Prevent Acute Kidney Injury in Mechanically Ventilated COVID-19 Patient

Amarjeet Kumar, Ajeet Kumar, Chandni Sinha, Prabhat Kumar Singh, Chethan Vamshi, Gayatri D. Sagdeo
Volume 1, Issue 3-4, December 2021, Pages 51-53
Acute Kidney Injury (AKI) is one of the major complication of the Coronavirus Disease 2019 (COVID-19) infection, commonly manifested during the second week of infection. The pathophysiology and mechanisms of AKI in patients with COVID-19 have not been fully elucidated and seem to be multifactorial. There...

Why you should have a Perfusionist as Workforce in the Intensive Care Unit

Gabriele Melegari, Maria Chiara Franchini, Francesca Sola, Emanuela Testa, Alberto Barbieri
Volume 1, Issue 3-4, December 2021, Pages 58-59
Case Report

Acute Fulminant Eclampsia with Cardiopulmonary arrest, Pulmonary Oedema and PRES: Maternal and Fetal Outcome

Papa Dasari, M. Nithin
Volume 1, Issue 3-4, December 2021, Pages 54-57
Complicated eclampsia resulting in cardiac arrest and subsequent fetal and maternal survival is rare. A 25-year-old primigravida was referred after initial resuscitation for cardiac arrest following a maternal collapse during pregnancy due to eclampsia at 36 weeks of pregnancy. The diagnosis at referral...
Review Article

Mesenchymal Stem Cells in Sepsis: From Basic Research to Clinical Application

Junyi Sun, Xianfei Ding, Tongwen Sun
Volume 1, Issue 1-2, June 2021, Pages 2-10
Sepsis is a life-threatening organ dysfunction caused by a deregulated host response to infection, and is the most common cause of death in the intensive care unit. Although the pathogenesis of sepsis has made substantial progress, the current clinical treatment of sepsis is basically symptomatic treatment,...

Metabolic Resuscitation Therapy for Sepsis: Where to Go

Zhanguo Liu, Ping Chang
Volume 1, Issue 1-2, June 2021, Pages 34-35
Review Article

Overview of the Cardiotoxicity Induced by PD-1/PD-L1 Immune Checkpoint Inhibitor in Critical Care

Ruiting Li, Xiaojing Zou, Huaqing Shu, You Shang
Volume 1, Issue 1-2, June 2021, Pages 11-15
The Programmed Cell Death 1 (PD-1)/Programmed Death Ligand 1 (PD-L1) Immune Checkpoint Inhibitors (ICIs), have become a hot spot in the field of cancer research and treatment, and bring new hope to patients with advanced tumors. But, in addition to enhancing the anti-tumor effect of T cells, PD-1/PD-L1...
Case Report

Unusually High Global End Diastolic Index Associated with Optimal Cardiac Index in Two Critically Ill Patients

Xiaoqing Wu, Desheng Chen, Chen Li, Jun Duan
Volume 1, Issue 1-2, June 2021, Pages 31-33
The optimal management of hemodynamic disorders among critically ill patients requires an accurate assessment of hemodynamic status. Global End Diastolic Index (GEDI) is taken for a more reliable indicator of preload in critically ill patients than central venous pressure and doctors tend to arrange...
Research Article

Preliminary Efficacy of Tocilizumab Treatment in the Patients with COVID-19

Yu Chen, Xijing Zhang
Volume 1, Issue 1-2, June 2021, Pages 24-30
Background: Interleukin-6 (IL-6) was considered to be with the severity and mortality in COVID-19 patients, which implies a potential therapeutic target for treatment. We aimed to evaluate the safety and initial efficacy of Tocilizumab treatment for COVID-19 patients. Methods: In the retrospective study,...
Research Article

The Incidence and Prognosis of ICU Delirium: A Retrospective Study from a Single Center

Qing Feng, Yuhang Ai, Meilin Ai, Li Huang, Qianyi Peng, Lina Zhang
Volume 1, Issue 1-2, June 2021, Pages 16-23
Purpose: Delirium is a frequent occurrence amongst Intensive Care Unit (ICU) patients, but studies on its causes are sparse and its risk factors vary from disease to disease. Here, in this study, an attempt was made to investigate the factors associated with the prognosis of delirium in the ICU. Methods:...