Exploring the Microbiota-Gut-Brain Axis for Mental Disorders with Knowledge Graphs
- https://doi.org/10.2991/jaims.d.201208.001How to use a DOI?
- Microbiota-gut-brain axis, Gut microbiota, Neurotransmitter, Mental disorder, Knowledge graph, Biomedical ontology
Gut microbiota has a significant influence on brain-related diseases through the communication routes of the gut-brain axis. Many species of gut microbiota produce a variety of neurotransmitters. In essence, the neurotransmitters are chemicals that influence mood, cognition, and behavior of the host. The relationships between gut microbiota and neurotransmitters has received much attention in medical and biomedical research. However, the integration of the various proposed neurotransmitter signal routes that underpin these relationships has not yet been studied well. To unlock the influence of gut microbiota on mental health via neurotransmitters, the microbiota-gut-brain (MGB) axis, we gather the decentralized results in the existing studies into a structured knowledge base. In this paper, we therefore propose a novel Microbiota Knowledge Graph based on a newly constructed knowledge graph for uncovering the potential associations among gut microbiota, neurotransmitters, and mental disorders which we refer to as MiKG. It includes many interfaces that link to well-known biomedical ontologies, e.g. UMLS, MeSH, KEGG, and SNOMED CT, and is extendable by linking to future ontologies to further exploit the relationships between gut microbiota and neurotransmitters. This paper present MiKG, an effective knowledge graph, that can be used to investigate the MGB axis using the relationships among gut microbiota, neurotransmitters, and mental disorders.
- © 2021 The Authors. Published by Atlantis Press B.V.
- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - JOUR AU - Ting Liu AU - Xueli Pan AU - Xu Wang AU - K. Anton Feenstra AU - Jaap Heringa AU - Zhisheng Huang PY - 2020 DA - 2020/12/15 TI - Exploring the Microbiota-Gut-Brain Axis for Mental Disorders with Knowledge Graphs JO - Journal of Artificial Intelligence for Medical Sciences SP - 30 EP - 42 VL - 1 IS - 3-4 SN - 2666-1470 UR - https://doi.org/10.2991/jaims.d.201208.001 DO - https://doi.org/10.2991/jaims.d.201208.001 ID - Liu2020 ER -